Hypnotics / DORA

Mechanism

졸피뎀은 GABA-A α1 선호 Z-drug. DORA(렘보렉산트)는 각성을 유지하는 orexin OX1/OX2를 막습니다.

Medicinal chemistry

이미다조피리딘 Z-drug vs 이중 orexin 길항 아미드.

Structure families

• Sleep / hypnotic series8 compounds

Key drugs · payloads

• Lemborexant (Dayvigo)Drug
• Zolpidem (Ambien)Drug
• Daridorexant (Quviviq)Drug
• Eszopiclone (Lunesta)Drug
• Suvorexant (Belsomra)Drug
• Zaleplon (Sonata)Drug

BioMoa