Interactive chemical structure analysis
Explore drug chemistry as a connected landscape.
Map scaffolds, compounds, drugs, payloads, and SAR relationships through interactive chemical structure networks.
Featured families
View all families →- KRAS inhibitor
KRAS G12C inhibitor chemical landscape
Shared acrylicamide / warhead chemotype from core scaffold to sotorasib, adagrasib, daraxonrasib and SAR analogs.
Explore → - EGFR TKI
EGFR tyrosine kinase inhibitor series
Quinazoline / aminopyrimidine core to 1st-gen drugs and 3rd-gen osimertinib (Tagrisso) with resistance mutations.
Explore → - ADC payload
MMAE (auristatin) payload family
Microtubule-disrupting auristatin payloads derived from dolastatin 10 — widely used in approved and clinical ADCs.
Explore → - GLP-1 / incretin
GLP-1 / incretin agonist series
GLP-1 receptor agonist chemotypes from exenatide/liraglutide to semaglutide, dual GIP/GLP-1 tirzepatide, triple agonists, and oral small-molecule orforglipron.
Explore → - PCSK9 / LDL-C
PCSK9 inhibitor chemical & modality series
Oral macrocyclic peptide PCSK9i (enlicitide / Lipfendra) mapped with injectable mAb (evolocumab, alirocumab) and siRNA (inclisiran) class peers for LDL-C lowering.
Explore → - Antidepressant · SSRI/SNRI
SSRI / SNRI antidepressant series
Aryloxy-propylamine pharmacophore from fluoxetine and sertraline to escitalopram and venlafaxine.
Explore →
Core tools
Analysis showcase
From scaffold to drug landscape
A curated KRAS G12C slice: abstract warhead, SAR analog, approved drug, and a class neighbor. Edges are catalog relationships, not inferred potency.
Open KRAS G12C graphMethodology
How it works →Fingerprints, similarity, clustering, and exploration scores are documented.
StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.
How similarity is calculated · How clustering works · How exploration priority is scored
Contact
Questions, feedback, structure/data corrections, or collaboration inquiries are welcome.