kras-g12c · egfr-inhibitors
최대 4개 패밀리를 선택해 비교합니다.
Payload: kras-adc-payload-1
Shared acrylicamide / warhead chemotype from core scaffold to sotorasib, adagrasib, daraxonrasib and SAR analogs.
맵 열기 →Quinazoline / aminopyrimidine core to 1st-gen drugs and 3rd-gen osimertinib (Tagrisso) with resistance mutations.
맵 열기 →Morgan fingerprint, radius 2, 2048 bits, Tanimoto. This value does not predict potency, biological activity, safety, or clinical efficacy.
| KRAS G12C inhibitor chemical landscape | EGFR tyrosine kinase inhibitor series | |
|---|---|---|
| KRAS G12C inhibitor chemical landscape | 1.00 | 0.07 |
| EGFR tyrosine kinase inhibitor series | 0.07 | 1.00 |