패밀리 비교 | StructureMoa

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PCSK9 inhibitor chemical & modality series

PCSK9 / LDL-C

화합물 9
관계 28
SMILES 9/9

Drug: 5
Derivative: 3
Scaffold: 1

Oral macrocyclic peptide PCSK9i (enlicitide / Lipfendra) mapped with injectable mAb (evolocumab, alirocumab) and siRNA (inclisiran) class peers for LDL-C lowering.

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ADC linker chemical families

ADC linker

화합물 8
관계 18
SMILES 8/8

Linker: 7
Scaffold: 1

Cleavable and non-cleavable linker scaffolds used across auristatin, maytansinoid, and TOP1 ADCs.

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패밀리 간 overlap

pcsk9-inhibitors ↔ adc-linkers · 평균 유사도(상위 쌍): 0.39

Core-compound Morgan similarity

Morgan fingerprint, radius 2, 2048 bits, Tanimoto. This value does not predict potency, biological activity, safety, or clinical efficacy.

	PCSK9 inhibitor chemical & modality series	ADC linker chemical families
PCSK9 inhibitor chemical & modality series	1.00	0.13
ADC linker chemical families	0.13	1.00