| Cleavable linker scaffoldAbstract scaffoldcleavable-linker-scaffoldPage | Scaffold | CC(C)C[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O… | — | — | linker · core · Linker for antibody conjugation. Anchor for the ADC linker chemical families lineage. |
| CL2A familyLinkercl2a-familyPage | Linker | NC(CCCNC(=O)CNC(=O)CCCCCN)C(=O)Nc1ccc(CO)c… | Cleavable linker scaffold | 23%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · cleavable · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| GGFG familyLinkerggfg-familyPage | Linker | NCC(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NCC(=O)O | Cleavable linker scaffold | 19%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · cleavable · DXd · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| Hydrazone familyLinkerhydrazone-familyPage | Linker | NNC(=O)c1ccc(C(=O)O)cc1 | Cleavable linker scaffold | 14%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · acid-sensitive · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| Mc-VC-PABC familyLinkermc-vc-pabc-familyPage | Linker | O=C(CCCCCN1C(=O)C=CC1=O)N[C@@H](C(C)C)C(=O… | Cleavable linker scaffold | 34%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · cleavable · cathepsin · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| SMCC familyLinkersmcc-familyPage | Linker | O=C(CCCCCN1C(=O)C=CC1=O)NCCCC[C@@H]1NC(=O)… | Cleavable linker scaffold | 12%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · non-cleavable · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| Sulfo-SPDB familyLinkersulfo-spdb-familyPage | Linker | O=C(CCCC[C@@H]1NC(=O)CNC1)SSCC(=O)Nc1ccc(S… | Cleavable linker scaffold | 7%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · cleavable · disulfide · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| Val-Cit familyLinkerval-cit-familyPage | Linker | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=O)N)NC(=O)C… | Cleavable linker scaffold | 38%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · cleavable · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |