Lorazepam (Ativan) structure · Anxiolytic · GABA

Lorazepam (Ativan) 2D structure

Role: Drug
Family: Benzodiazepine GABA-A modulators
Mechanism class: Anxiolytic · GABA
Parent scaffold: 1,4-Benzodiazepine core

Structure source: Catalog seed (external identifier on file)
PubChem CID: 3958
ChEMBL ID: CHEMBL697

How similarity is calculated

Hand-written analysis

Mechanism

로라제팜도 GABA-A 벤조디아제핀 부위 작용입니다. 글루쿠론산 포함이라 간 산화가 적은 편입니다. 반감기가 디아제팜보다 짧습니다.

Medicinal chemistry

3-하이드록시 1,4-벤조디아제핀입니다. 산화 대사 의존이 적어 고령·간질환에서 자주 고릅니다.

Indication · context

급성 불안·초조·경련에 쓰입니다. 디아제팜과 대사·지속시간을 비교합니다.

SMILES

OC1N=C(C2=CC=CC=C2)C3=C(N1C(=O)C)C=CC(Cl)=C3

Related compounds

External IDs · BioMoa

PubChem CID 3958 CHEMBL697 BioMoa · CNS / GABA BioMoa bridge Open on the family map Flow Structure table CNS Deep Analysis Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

Lorazepam (Ativan) structure · mechanism