Retatrutide (LY3437943) structure · GLP-1 / incretin

Retatrutide (LY3437943) 2D structure

Role: Drug
Family: GLP-1 / incretin agonist series
Mechanism class: GLP-1 / incretin
Parent scaffold: Tirzepatide (Mounjaro / Zepbound)

Structure source: Catalog seed

How similarity is calculated

Hand-written analysis

Mechanism

레타트루타이드는 GIP/GLP-1/글루카곤 삼중 작용 펩타이드입니다. 이중(티르제파타이드)에서 글루카곤 축을 더합니다. GI 부작용은 인크레틴 클래스와 겹칩니다.

Medicinal chemistry

아실화 단일 사슬에 세 수용체 활성을 넣습니다. 세마글루타이드(GLP-1 단일)와 케모타입 층이 다릅니다.

Indication · context

비만·대사 임상 자산입니다. 인크레틴 맵에서 단일·이중·삼중·경구를 나눕니다.

SMILES

N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O

Related compounds

External IDs · BioMoa

PubChem 검색 ChEMBL 검색 PubChem (SMILES)BioMoa · Triple agonist / retatrutide BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

Retatrutide (LY3437943) structure · mechanism