MMAF (monomethyl auristatin F) structure · ADC payload

MMAF (monomethyl auristatin F) 2D structure

Role: Payload
Family: MMAE (auristatin) payload family
Mechanism class: ADC payload
Parent scaffold: Dolastatin 10 / auristatin core

Structure source: Catalog seed

How similarity is calculated

Hand-written analysis

Mechanism

모노메틸 아우리스타틴 F(MMAF)는 미세소관 중합 저해제 payload입니다. 카르복실레이트 전하 때문에 막투과가 MMAE보다 낮고 세포 잔류가 큽니다. bystander가 적습니다.

Medicinal chemistry

아우리스타틴 펩타이드에 C-말단 페닐알라닌 산이 있습니다. MMAE의 노르에페드린과 전하가 갈립니다.

Indication · context

일부 vedotin/마포도틴 ADC의 워헤드입니다. MMAE와 bystander·독성 장기를 비교합니다.

SMILES

CC(C)C1=NC(=CS1)C2=CC(=C(C=C2)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)NC(=O)[C@@H](Cc4ccccc4)C(=O)O)NC(=O)C(C)C

Related compounds

External IDs · BioMoa

PubChem 검색 ChEMBL 검색 PubChem (SMILES)BioMoa · BioMoa에서 검색 BioMoa · Auristatin ADC BioMoa · Taxane / microtubule BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

MMAF (monomethyl auristatin F) structure · mechanism