Drug · MS · S1P · MS · S1P · Verified drug
Fingolimod (Gilenya) structure · mechanism
Fingolimod (Gilenya) 2D structure
- Role
- Drug
- Family
- MS S1P modulator series
- Mechanism class
- MS · S1P
- Parent scaffold
- Sphingosine-like pharmacophore
- Indication
- Relapsing MS · FDA/EMA
- Structure source
- Catalog seed
- FDA / EMA
- FDA/EMA
- ClinicalTrials.gov
- fingolimod multiple sclerosis
- Regulatory status
- Approved · FDA/EMA · ClinicalTrials.gov · ClinicalTrials.gov
Hand-written analysis
Mechanism
핑골리모드는 S1P 수용체 조절 프로드러그입니다. S1P1 내재화로 림프구가 림프절에 갇혀 MS 재발이 줄어듭니다. 초회 서맥·감염·황반부종을 봅니다.
Medicinal chemistry
스핑고신 유사 아미노디올입니다. 시포니모드·오자니모드는 선택적 후속입니다.
Indication · context
재발 MS. S1P 허브의 1세대입니다.
SMILES
CCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)NTags
Related compounds
External IDs · BioMoa
StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.