| PBD monomer (anthramycin lineage)Abstract pharmacophorepbd-monomer-corePage | Scaffold | CC1=CN(C2=C1C=C(C=C2)OC)C3=CC4=C(C=C3)N(C(… | — | — | PBD · DNA-alkylator · core · Shared pharmacophore / core scaffold. Anchor for the PBD dimer ADC payload family lineage. |
| SG3199 (PBD dimer warhead)Payloadsg3199Page | Payload | CC1=CN2C(=C1C)C=NC3=CC(=C(C=C3C2=O)OC)OCCC… | PBD monomer (anthramycin lineage) | 45%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | payload · DNA crosslink · Payload warhead chemistry. Released warhead after lysosomal cleavage. |
| Tesirine (SG3249)PayloadtesirinePage | Payload | CC1=CN2C(=C1C)C=NC3=CC(=C(C=C3C2=O)OC)OCCC… | SG3199 (PBD dimer warhead) | 30%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | ADC · payload · ADC platform member. Released warhead after lysosomal cleavage. |
| Val-Ala PBD linkerLinkerval-ala-pbd-linkerPage | Linker | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)C)C… | PBD monomer (anthramycin lineage) | 4%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · cleavable · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| Camidanlumab tesirineADCcamidanlumab-tesirinePage | ADC | CC1=CN2C(=C1C)C=NC3=CC(=C(C=C3C2=O)OC)OCCC… | Tesirine (SG3249) | 30%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | ADC · CD25 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Camidanluma… |
| PBD-ADC example constructADCpbd-adc-examplePage | ADC | CC1=CN2C(=C1C)C=NC3=CC(=C(C=C3C2=O)OC)OCCC… | SG3199 (PBD dimer warhead) | 45%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | ADC · preclinical · Antibody-drug conjugate construct; displayed structure is the payload warhead (PBD-ADC exa… |