MK-0616 (enlicitide development code) structure · PCSK9 / LDL-C

MK-0616 (enlicitide development code) 2D structure

Role: Derivative
Family: PCSK9 inhibitor chemical & modality series
Mechanism class: PCSK9 / LDL-C
Parent scaffold: Enlicitide (Lipfendra)

Structure source: StructureMoa-defined exploratory node

How similarity is calculated

Hand-written analysis

Mechanism

엔리시타이드(MK-0616)는 경구 PCSK9 매크로사이클입니다. 항체·siRNA가 아닌 소분자/펩타이드 유사 경구로 PCSK9–LDLR 축을 겨냥합니다.

Medicinal chemistry

경구 매크로사이클 케모타입입니다. 에볼로쿠맙·인클리시란과 개입 층이 다릅니다.

Indication · context

LDL-C 경구 PCSK9 임상 자산입니다. /briefs/pcsk9-oral-sirna의 세 번째 축입니다.

SMILES

CC(C)C[C@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CCCCCCCCC(=O)O)CCC(=O)N1

Related compounds

External IDs · BioMoa

PubChem 검색 ChEMBL 검색 PubChem (SMILES)BioMoa · MK-0616 / enlicitide BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

MK-0616 (enlicitide development code) structure · mechanism