Topotecan (Hycamtin) structure · TOP1 inhibitor

Topotecan (Hycamtin) 2D structure

Role: Drug
Family: SN-38 / irinotecan (TOP1) small-molecule series
Mechanism class: TOP1 inhibitor
Parent scaffold: Camptothecin (parent alkaloid)

Structure source: Catalog seed

How similarity is calculated

Hand-written analysis

Mechanism

토포테칸은 TOP1 저해제 캠토테신 유사체입니다. 이리노테칸/SN-38과 효소는 같고 치환·적응(난소·소세포폐)이 다릅니다. 골수억제가 고전적입니다.

Medicinal chemistry

캠토테신 A환 치환으로 수용성을 올린 분자입니다. 락톤-카르복실레이트 평형이 활성에 중요합니다.

Indication · context

세포독성 전신 요법입니다. SN-38 ADC·DXd와 같은 TOP1 층을 혼동하지 마십시오.

SMILES

CC1=CC2=C(C=C1)N(C3=NC(C(=O)O)=NC4=CC=CC=C43)C(CO)O2

Related compounds

External IDs · BioMoa

PubChem 검색 ChEMBL 검색 PubChem (SMILES)BioMoa · BioMoa에서 검색 BioMoa · TOP1 ADC (DXd)BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

Topotecan (Hycamtin) structure · mechanism