Cobimetinib (Cotellic) structure · BRAF / MEK

Cobimetinib (Cotellic) 2D structure

Role: Drug
Family: BRAF / MEK inhibitor chemical series
Mechanism class: BRAF / MEK
Parent scaffold: BRAF hinge-binding aryl core

Structure source: Catalog seed

How similarity is calculated

Hand-written analysis

Mechanism

코비메티닙은 알로스테릭 MEK1/2 저해제입니다. 베무라페닙과 짝을 이뤄 MAPK를 이중 차단합니다. 심근·망막·발진은 MEK 클래스 독성입니다.

Medicinal chemistry

ATP 자리가 아닌 알로스테릭 포켓 리간드입니다. 트라메티닙과 같은 층, 다른 치환입니다.

Indication · context

BRAF V600 병용 파트너입니다. MEK 세 약을 한 맵에 둡니다.

SMILES

COC(=O)NC1=CC(=C(C=C1)F)C(=O)N2CCC[C@@H]([C@@H]2C3=CC=C(C=C3)Cl)NC(=O)C4=CC(=C(C=C4)F)F

Related compounds

External IDs · BioMoa

PubChem 검색 ChEMBL 검색 PubChem (SMILES)BioMoa · MEK / Cotellic BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

Cobimetinib (Cotellic) structure · mechanism