Drug · BRAF / MEK · BRAF / MEK · Verified drug
Encorafenib (Braftovi) structure · mechanism
Encorafenib (Braftovi) 2D structure
- Role
- Drug
- Mechanism class
- BRAF / MEK
- InChIKey
CMJCXYNUCSMDBY-ZDUSSCGKSA-N- Parent scaffold
- BRAF hinge-binding aryl core
- Structure source
- Catalog seed
- InChI Key
- CMJCXYNUCSMDBY-ZDUSSCGKSA-N
Hand-written analysis
Mechanism
엔코라페닙은 BRAF V600 type I 저해제입니다. 비니메티닙(MEK) 병용이 표준 짝입니다. paradoxical RAF 활성화는 이 클래스 공통입니다.
Medicinal chemistry
설폰아마이드 케모타입으로 베무라페닙(아자인돌)·다브라페닙(티아졸)과 코어가 갈립니다.
Indication · context
흑색종·일부 대장암 V600. BRAF/MEK 허브에서 세 짝을 비교합니다.
SMILES
COC(=O)N[C@H](CNc1nccc(n1)c1cn(nc1c1cc(Cl)cc(c1F)NS(=O)(=O)C)C(C)C)CTags
Related compounds
External IDs · BioMoa
StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.