| Enediyne warhead coreAbstract pharmacophoreenediyne-warhead-corePage | Scaffold | C#C/C=C\C#C[C@H]1OC(=O)[C@H]([C@H](O1)OC)C… | — | — | enediyne · DNA-cleave · core · Shared pharmacophore / core scaffold. Anchor for the Calicheamicin enediyne payload family… |
| Calicheamicin γ¹Payloadcalicheamicin-gammaPage | Payload | C#C/C=C\C#C[C@H]1OC(=O)[C@H]([C@H](O1)OC)C… | Enediyne warhead core | 69%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | payload · natural product · Payload warhead chemistry. Released warhead after lysosomal cleavage. |
| N-acetyl-γ-calicheamicinPayloadnac-calicheamicinPage | Payload | C#C/C=C\C#C[C@H]1OC(=O)[C@H]([C@H](O1)OC)C… | Calicheamicin γ¹ | 61%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | payload · ADC-active · Payload warhead chemistry. Released warhead after lysosomal cleavage. |
| Acyl hydrazone linkerLinkerhydrazone-linkerPage | Linker | NNC(=O)c1ccccc1 | Enediyne warhead core | 4%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | linker · acid-sensitive · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| Gemtuzumab ozogamicin (Mylotarg)ADCgemtuzumab-ozogamicinPage | ADC | C#C/C=C\C#C[C@H]1OC(=O)[C@H]([C@H](O1)OC)C… | N-acetyl-γ-calicheamicin | 61%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | ADC · approved · CD33 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Gemtuzumab … |
| Inotuzumab ozogamicin (Besponsa)ADCinotuzumab-ozogamicinPage | ADC | C#C/C=C\C#C[C@H]1OC(=O)[C@H]([C@H](O1)OC)C… | N-acetyl-γ-calicheamicin | 61%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | ADC · approved · CD22 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Inotuzumab … |