KRAS G12D / RAS(ON) inhibitor series

KRAS inhibitorRefresh recommended

Non-covalent and RAS(ON) chemotypes targeting KRAS G12D — MRTX1133, RMC-6236, RMC-9805 and SAR analogs.

Mechanism · KRAS inhibitor BioMoa · KRAS inhibitor 프로그램 BioMoa bridge · shared ID

Last analysis: 7/20/2026, 2:09:01 AM · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed
Last updated: 7/20/2026, 2:09:01 AM
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 4
Exploratory nodes: 2
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
KRAS G12D core scaffoldAbstract pharmacophorekras-g12d-corePage	Scaffold	`c1ccc2c(c1)nc(nc2N)N1CCCCC1`	—	—	KRAS G12D · core · Shared pharmacophore / core scaffold. Anchor for the KRAS G12D / RAS(ON) inhibitor series …
Aspograstat (HRS-4642-class G12D)Known compoundaspograstatPage	Drug	`CC1CN(CC1C)C(=O)c2ccc(F)cc2Nc3nc(nc3c4ccc(…`	KRAS G12D core scaffold	—	clinical · KRAS G12D · Clinical-stage candidate. Aspograstat (HRS-4642-class G12D) in this family map.
MRTX1133Known compoundmrtx1133Page	Drug	`CC1=C(C=C(C=C1)C2=NC(=NC(=C2)N3CCN(CC3)C)N…`	KRAS G12D core scaffold	16%i	clinical · KRAS G12D · Clinical-stage candidate. MRTX1133 in this family map.
RMC-6236 (daraxonrasib, RAS(ON))Known compoundrmc6236Page	Drug	`CC1CN(CC1C)C(=O)c2nc(Nc3cccc(F)c3)c(n2)c4c…`	KRAS G12D core scaffold	—	clinical · multi-RAS · RAS(ON) · Clinical-stage candidate. RMC-6236 (daraxonrasib, RAS(ON)) in this family map.
RMC-9805 (G12D RAS(ON))Known compoundrmc9805Page	Drug	`CC1CN(CC1C)C(=O)c2nc(Nc3cccc(Cl)c3)c(n2)c4…`	KRAS G12D core scaffold	—	clinical · KRAS G12D · RAS(ON) · Clinical-stage candidate. RMC-9805 (G12D RAS(ON)) in this family map.
G12D fluoro-aryl SAR analogExploratory analog (rule-generated)g12d-sar-fluoroarylPage	Derivative	`CC1=C(C=C(C=C1)C2=NC(=NC(=C2)N3CCN(CC3)C)N…`	G12D SAR piperidine analog	15%i	SAR · F-scan · SAR exploration node. Derived analog of parent node in KRAS G12D / RAS(ON) inhibitor serie…
G12D SAR piperidine analogExploratory analog (rule-generated)g12d-sar-piperidinePage	Derivative	`CC1=C(C=C(C=C1)C2=NC(=NC(=C2)N3CCCCC3)NC4=…`	MRTX1133	21%i	SAR · SAR exploration node. Derived analog of parent node in KRAS G12D / RAS(ON) inhibitor serie…

From the core chemical, derivatives, drugs, and payloads fan out. Dashed orange chords are drug–drug links (spider web).

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