Parkinson dopaminergic / MAO-B series

ParkinsonNot analyzed

Levodopa pathway, dopamine agonists, and MAO-B inhibitors used in Parkinson disease.

Mechanism · Parkinson BioMoa · Parkinson / CNS BioMoa bridge · shared ID

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Data sources: Catalog seed · ClinicalTrials.gov · FDA/EMA
Last updated: Not recorded
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 9
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Catecholamine / amino-acid coreAbstract pharmacophorepd-catecholamine-corePage	Scaffold	`NC(Cc1ccc(O)c(O)c1)C(=O)O`	—	—	Parkinson · core · dopamine · Shared pharmacophore / core scaffold. Anchor for the Parkinson dopaminergic / MAO-B series…
CarbidopaVerified drugcarbidopaPage	Drug	`C[C@@](N)(Cc1ccc(O)c(O)c1)C(=O)O`	Catecholamine / amino-acid core	—	Parkinson · FDA · AADC inhibitor · Clinical or approved drug node — Carbidopa.
Entacapone (Comtan)Verified drugentacaponePage	Drug	`CCN(CC)C(=O)C(=CC1=CC(=C(C(=C1)O)O)[N+](=O…`	Catecholamine / amino-acid core	—	Parkinson · FDA · approved · COMT inhibitor · Approved therapeutic. Entacapone (Comtan) in this family map.
Levodopa (L-DOPA)Verified druglevodopaPage	Drug	`N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O`	Catecholamine / amino-acid core	—	Parkinson · FDA · approved · dopamine precursor · Approved therapeutic. Levodopa (L-DOPA) in this family map.
Pramipexole (Mirapex)Verified drugpramipexolePage	Drug	`CCCNc1nc2c(s1)CC[C@@H](N)C2`	Catecholamine / amino-acid core	—	Parkinson · FDA · D2/D3 agonist · Clinical or approved drug node — Pramipexole (Mirapex).
Rasagiline (Azilect)Verified drugrasagilinePage	Drug	`C#CCN[C@@H]1CCc2ccccc21`	Catecholamine / amino-acid core	—	Parkinson · FDA · MAO-B · Clinical or approved drug node — Rasagiline (Azilect).
Ropinirole (Requip)Verified drugropinirolePage	Drug	`CCCN(CCC)CCc1cccc2[nH]c(=O)cc12`	Catecholamine / amino-acid core	—	Parkinson · FDA · D2 agonist · Clinical or approved drug node — Ropinirole (Requip).
Rotigotine (Neupro)Verified drugrotigotinePage	Drug	`CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O`	Catecholamine / amino-acid core	—	Parkinson · FDA · approved · D2/D3 agonist · Approved therapeutic. Rotigotine (Neupro) in this family map.
Safinamide (Xadago)Verified drugsafinamidePage	Drug	`CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F`	Catecholamine / amino-acid core	—	Parkinson · FDA · approved · MAO-B · Approved therapeutic. Safinamide (Xadago) in this family map.
Selegiline (Eldepryl)Verified drugselegilinePage	Drug	`C#CCN(C)[C@H](C)Cc1ccccc1`	Catecholamine / amino-acid core	—	Parkinson · FDA · MAO-B · Clinical or approved drug node — Selegiline (Eldepryl).
Fluoro-catechol analogExploratory analog (rule-generated)pd-fluoro-catechol-analogPage	Derivative	`NC(Cc1cc(F)c(O)c(O)c1)C(=O)O`	Catecholamine / amino-acid core	—	SAR · F-scan · SAR exploration node. Derived analog of parent node in Parkinson dopaminergic / MAO-B seri…

Name	Role	Derived from	Sim. to core	Relations	Tags
CarbidopaVerified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core · related_drug: Levodopa (L-DOPA)	Parkinson, FDA, AADC inhibitor
Catecholamine / amino-acid coreAbstract pharmacophore	Scaffold	—	—	derived_from: Levodopa (L-DOPA) · derived_from: Carbidopa · derived_from: Pramipexole (Mirapex) · derived_from: Ropinirole (Requip) · derived_from: Selegiline (Eldepryl) · derived_from: Rasagiline (Azilect) · derived_from: Entacapone (Comtan) · derived_from: Rotigotine (Neupro) · derived_from: Fluoro-catechol analog · derived_from: Safinamide (Xadago)	Parkinson, core, dopamine
Entacapone (Comtan)Verified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core · related_drug: Levodopa (L-DOPA)	Parkinson, FDA, approved, COMT inhibitor
Fluoro-catechol analogExploratory analog (rule-generated)	Derivative	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core	SAR, F-scan
Levodopa (L-DOPA)Verified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core · related_drug: Carbidopa · related_drug: Entacapone (Comtan)	Parkinson, FDA, approved, dopamine precursor
Pramipexole (Mirapex)Verified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core · similar_to: Rotigotine (Neupro)	Parkinson, FDA, D2/D3 agonist
Rasagiline (Azilect)Verified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core · similar_to: Selegiline (Eldepryl)	Parkinson, FDA, MAO-B
Ropinirole (Requip)Verified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core	Parkinson, FDA, D2 agonist
Rotigotine (Neupro)Verified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core · similar_to: Pramipexole (Mirapex)	Parkinson, FDA, approved, D2/D3 agonist
Safinamide (Xadago)Verified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core	Parkinson, FDA, approved, MAO-B
Selegiline (Eldepryl)Verified drug	Drug	Catecholamine / amino-acid core	—	derived_from: Catecholamine / amino-acid core · similar_to: Rasagiline (Azilect)	Parkinson, FDA, MAO-B

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Clinical · regulatory context

Parkinson — 승인·병용 중심

L-DOPA ± AADC/COMT/MAO-B와 도파민 작용제가 표준. 구조적으로 가까운 이웃이라도 임상 적응증·병용 맥락이 다릅니다.

Approved/clinical labels here come from the catalog clinical overlay. Agency names are shown when curated; live FDA/EMA APIs are not called.

LevodopaApprovedFDA/EMA
Parkinson disease motor symptoms
ClinicalTrials.gov
RasagilineApprovedFDA/EMA
PD (MAO-B); early/adjunct
Selegiline과 propargyl 유사 — 임상 포지션은 다름
ClinicalTrials.gov
PramipexoleApprovedFDA/EMA
PD; restless legs
ClinicalTrials.gov

Program and pipeline notes live on BioMoa · cns · StructureMoa ↔ BioMoa bridge