RET / MET / NTRK oncogene TKI series

RET / MET / NTRK TKIRefresh recommended

Multi-kinase hinge pharmacophore spanning selective RET, MET, and NTRK inhibitors.

Mechanism · RET / MET / NTRK TKI BioMoa · RET / MET / NTRK BioMoa bridge · shared ID

Last analysis: 7/20/2026, 2:10:05 AM · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed
Last updated: 7/20/2026, 2:10:05 AM
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 7
Exploratory nodes: 0
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Multi-kinase hinge coreAbstract pharmacophoreoncogene-hinge-corePage	Scaffold	`c1cc2c(ncnc2n1)N`	—	—	RET · MET · NTRK · core · Shared pharmacophore / core scaffold. Anchor for the RET / MET / NTRK oncogene TKI series …
Capmatinib (Tabrecta)Verified drugcapmatinibPage	Drug	`CN1C=C(C=N1)C2=CC3=C(C=C2)N=C(N3)NC4=CC=C(…`	Multi-kinase hinge core	—	approved · MET · Approved therapeutic. Capmatinib (Tabrecta) in this family map.
Entrectinib (Rozlytrek)Verified drugentrectinibPage	Drug	`CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC(=NC(=C3)C4…`	Multi-kinase hinge core	—	approved · NTRK · ROS1 · Approved therapeutic. Entrectinib (Rozlytrek) in this family map.
Larotrectinib (Vitrakvi)Verified druglarotrectinibPage	Drug	`CC1=C(C=CC(=C1)F)C2=NC(=NC(=C2)N3CCN(CC3)C…`	Multi-kinase hinge core	—	approved · NTRK · Approved therapeutic. Larotrectinib (Vitrakvi) in this family map.
Pralsetinib (Gavreto)Verified drugpralsetinibPage	Drug	`CC1=CC(=CC(=C1)C2=NC(=NC(=C2)N3CCC(CC3)N)N…`	Multi-kinase hinge core	—	approved · RET · Approved therapeutic. Pralsetinib (Gavreto) in this family map.
Repotrectinib (Augtyro)Verified drugrepotrectinibPage	Drug	`CC1CN(CC1)C2=NC(=NC(=C2)C3=CC=CC(=C3)F)NC4…`	Multi-kinase hinge core	—	approved · NTRK · ROS1 · Approved therapeutic. Repotrectinib (Augtyro) in this family map.
Selpercatinib (Retevmo)Verified drugselpercatinibPage	Drug	`CC1=CC(=C(C=C1)C2=NC(=NC(=C2)N3CCN(CC3)C)N…`	Multi-kinase hinge core	—	approved · RET · Approved therapeutic. Selpercatinib (Retevmo) in this family map.
Tepotinib (Tepmetko)Verified drugtepotinibPage	Drug	`COC1=CC=C(C=C1)C2=NC(=NC(=C2)N3CCOCC3)NC4=…`	Multi-kinase hinge core	—	approved · MET · Approved therapeutic. Tepotinib (Tepmetko) in this family map.

Name	Role	Derived from	Sim. to core	Relations	Tags
Capmatinib (Tabrecta)Verified drug	Drug	Multi-kinase hinge core	—	derived_from: Multi-kinase hinge core · similar_to: Tepotinib (Tepmetko) · related_drug: Tepotinib (Tepmetko)	approved, MET
Entrectinib (Rozlytrek)Verified drug	Drug	Multi-kinase hinge core	—	derived_from: Multi-kinase hinge core · similar_to: Larotrectinib (Vitrakvi)	approved, NTRK, ROS1
Larotrectinib (Vitrakvi)Verified drug	Drug	Multi-kinase hinge core	—	derived_from: Multi-kinase hinge core · similar_to: Entrectinib (Rozlytrek) · related_drug: Repotrectinib (Augtyro)	approved, NTRK
Multi-kinase hinge coreAbstract pharmacophore	Scaffold	—	—	derived_from: Selpercatinib (Retevmo) · derived_from: Pralsetinib (Gavreto) · derived_from: Capmatinib (Tabrecta) · derived_from: Tepotinib (Tepmetko) · derived_from: Larotrectinib (Vitrakvi) · derived_from: Entrectinib (Rozlytrek) · derived_from: Repotrectinib (Augtyro)	RET, MET, NTRK, core
Pralsetinib (Gavreto)Verified drug	Drug	Multi-kinase hinge core	—	derived_from: Multi-kinase hinge core · similar_to: Selpercatinib (Retevmo) · related_drug: Selpercatinib (Retevmo) · similar_to: Repotrectinib (Augtyro)	approved, RET
Repotrectinib (Augtyro)Verified drug	Drug	Multi-kinase hinge core	—	derived_from: Multi-kinase hinge core · related_drug: Larotrectinib (Vitrakvi) · similar_to: Pralsetinib (Gavreto)	approved, NTRK, ROS1
Selpercatinib (Retevmo)Verified drug	Drug	Multi-kinase hinge core	—	derived_from: Multi-kinase hinge core · similar_to: Pralsetinib (Gavreto) · related_drug: Pralsetinib (Gavreto)	approved, RET
Tepotinib (Tepmetko)Verified drug	Drug	Multi-kinase hinge core	—	derived_from: Multi-kinase hinge core · similar_to: Capmatinib (Tabrecta) · related_drug: Capmatinib (Tabrecta)	approved, MET

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