Cabazitaxel (Jevtana) structure · Taxane / microtubule

Cabazitaxel (Jevtana) 2D structure

Role: Drug
Family: Taxane diterpenoid series
Mechanism class: Taxane / microtubule
Parent scaffold: Docetaxel (Taxotere)

Structure source: Catalog seed

How similarity is calculated

Hand-written analysis

Mechanism

카바지탁셀은 미세소관 안정화 탁산으로 P-gp 등 배출 펌프를 의식한 후속 분자입니다. 도세탁셀 이후 전립선암 라인에 쓰입니다. 호중구감소가 용량 제한입니다.

Medicinal chemistry

바카틴 코어의 메톡시 치환이 도세탁셀과 갈립니다. 탁산 디테르펜 골격은 유지됩니다.

Indication · context

전이 거세저항성 전립선암 등. 파클리탁셀·도세탁셀과 C13·C10 치환을 비교합니다.

SMILES

CC1=C2[C@H](C(=O)[C@@]3([C@H]([C@H]([C@]([C@H]([C@@H]4[C@H]([C@H]([C@@H](C4)O)O)OC(=O)C5=CC=CC=C5)O)(C3)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C6=CC=CC=C6)O)C)OC(=O)C)OC7=CC=CC=C7

Related compounds

External IDs · BioMoa

PubChem 검색 ChEMBL 검색 PubChem (SMILES)BioMoa · Taxane / Jevtana BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

Cabazitaxel (Jevtana) structure · mechanism