Taxane diterpenoid series

Taxane / microtubuleRefresh recommended

Paclitaxel core to docetaxel, cabazitaxel and semisynthetic analogs.

Mechanism · Taxane / microtubule BioMoa · Taxane / microtubule BioMoa bridge · shared ID

Last analysis: 7/20/2026, 2:10:17 AM · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed · PubChem · ChEMBL
Last updated: 7/20/2026, 2:10:17 AM
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 3
Exploratory nodes: 2
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Taxane tetracyclic coreAbstract pharmacophoretaxane-bicyclic-corePage	Scaffold	`CC1=C2[C@H](C(=O)[C@@]3([C@H]([C@H]([C@]([…`	—	—	taxane · microtubule · core · Shared pharmacophore / core scaffold. Anchor for the Taxane diterpenoid series lineage.
Cabazitaxel (Jevtana)Verified drugcabazitaxelPage	Drug	`CC1=C2[C@H](C(=O)[C@@]3([C@H]([C@H]([C@]([…`	Docetaxel (Taxotere)	—	approved · microtubule · Approved therapeutic. Cabazitaxel (Jevtana) in this family map.
Docetaxel (Taxotere)Verified drugdocetaxelPage	Drug	`CC1=C2[C@H](C(=O)[C@@]3([C@H]([C@H]([C@]([…`	Taxane tetracyclic core	—	approved · microtubule · Approved therapeutic. Docetaxel (Taxotere) in this family map. · CHEMBL92 · CID 148124
Paclitaxel (Taxol)Verified drugpaclitaxelPage	Drug	`CC1=C2[C@H](C(=O)[C@@]3([C@H]([C@H]([C@]([…`	Taxane tetracyclic core	—	approved · microtubule · Microtubule-stabilizing taxane — cornerstone cytotoxic. · CHEMBL428647 · CID 36314
Taxane C10 ester analogExploratory analog (rule-generated)taxane-c10-esterPage	Derivative	`CC1=C2[C@H](C(=O)[C@@]3([C@H]([C@H]([C@]([…`	Paclitaxel (Taxol)	—	SAR · SAR exploration node. Derived analog of parent node in Taxane diterpenoid series.
Taxane sidechain-modified analogExploratory analog (rule-generated)taxane-sidechain-modPage	Derivative	`CC1=C2[C@H](C(=O)[C@@]3([C@H]([C@H]([C@]([…`	Taxane C10 ester analog	—	SAR · SAR exploration node. Derived analog of parent node in Taxane diterpenoid series.

Name	Role	Derived from	Sim. to core	Relations	Tags
Cabazitaxel (Jevtana)Verified drug	Drug	Docetaxel (Taxotere)	—	derived_from: Docetaxel (Taxotere)	approved, microtubule
Docetaxel (Taxotere)Verified drug	Drug	Taxane tetracyclic core	—	derived_from: Taxane tetracyclic core · derived_from: Cabazitaxel (Jevtana) · similar_to: Paclitaxel (Taxol) · related_drug: Paclitaxel (Taxol)	approved, microtubule
Paclitaxel (Taxol)Verified drug	Drug	Taxane tetracyclic core	—	derived_from: Taxane tetracyclic core · derived_from: Taxane C10 ester analog · similar_to: Docetaxel (Taxotere) · related_drug: Docetaxel (Taxotere)	approved, microtubule
Taxane C10 ester analogExploratory analog (rule-generated)	Derivative	Paclitaxel (Taxol)	—	derived_from: Paclitaxel (Taxol) · derived_from: Taxane sidechain-modified analog	SAR
Taxane sidechain-modified analogExploratory analog (rule-generated)	Derivative	Taxane C10 ester analog	—	derived_from: Taxane C10 ester analog	SAR
Taxane tetracyclic coreAbstract pharmacophore	Scaffold	—	—	derived_from: Paclitaxel (Taxol) · derived_from: Docetaxel (Taxotere)	taxane, microtubule, core

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