SSRI / SNRI antidepressant series

Antidepressant · SSRI/SNRIRefresh recommended

Aryloxy-propylamine pharmacophore from fluoxetine and sertraline to escitalopram and venlafaxine.

Mechanism · Antidepressant · SSRI/SNRI BioMoa · CNS antidepressant BioMoa bridge · shared ID

Last analysis: 7/20/2026, 2:10:15 AM · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed · PubChem · ChEMBL · ClinicalTrials.gov · FDA/EMA
Last updated: 7/20/2026, 2:10:15 AM
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 6
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Aryloxy-propylamine coreAbstract pharmacophoressri-aryloxy-propylamine-corePage	Scaffold	`CNCCCOC1=CC=CC=C1`	—	—	SSRI · core · monoamine · Shared pharmacophore / core scaffold. Anchor for the SSRI / SNRI antidepressant series lin…
Escitalopram (Lexapro)Verified drugescitalopramPage	Drug	`CN[C@@H](CCCOC1=CC=C(C=C1)C#N)C2=CC=C(C=C2…`	Aryloxy-propylamine core	30%i	SSRI · S-enantiomer · Clinical or approved drug node — Escitalopram (Lexapro). · CHEMBL1508 · CID 146570
Fluoxetine (Prozac)Verified drugfluoxetinePage	Drug	`CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2`	Aryloxy-propylamine core	34%i	SSRI · FDA · 5-HT · Clinical or approved drug node — Fluoxetine (Prozac). · CHEMBL41 · CID 3386
Fluvoxamine (Luvox)Verified drugfluvoxaminePage	Drug	`COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F`	Aryloxy-propylamine core	—	SSRI · FDA · approved · Approved therapeutic. Fluvoxamine (Luvox) in this family map.
Paroxetine (Paxil)Verified drugparoxetinePage	Drug	`C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OC…`	Aryloxy-propylamine core	—	SSRI · FDA · approved · Approved therapeutic. Paroxetine (Paxil) in this family map.
Sertraline (Zoloft)Verified drugsertralinePage	Drug	`CN[C@H]1CC[C@@H](C2=CC(Cl)=C(Cl)C=C2)C[C@H…`	Aryloxy-propylamine core	12%i	SSRI · FDA · Clinical or approved drug node — Sertraline (Zoloft). · CHEMBL809 · CID 68617
Venlafaxine (SNRI)Known compoundvenlafaxinePage	Drug	`COC1=CC=C(C=C1)CC(CN(C)C)C2=CC=CC=C2Cl`	Aryloxy-propylamine core	18%i	SNRI · dual reuptake · Clinical or approved drug node — Venlafaxine (SNRI). · CHEMBL637 · CID 5656
Fluorine-walk analogExploratory analog (rule-generated)ssri-fluorine-walkPage	Derivative	`CNCCC(OC1=CC=C(C=C1)F)C2=CC=CC=C2`	Aryloxy-propylamine core	37%i	SAR · F-scan · SAR exploration node. Derived analog of parent node in SSRI / SNRI antidepressant series.

From the core chemical, derivatives, drugs, and payloads fan out. Dashed orange chords are drug–drug links (spider web).

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Clinical · regulatory context

SSRI/SNRI — 정신·통증 교차

동일 계열이라도 적응증(우울·불안·통증)과 블랙박스 경고가 공통입니다.

Approved/clinical labels here come from the catalog clinical overlay. Agency names are shown when curated; live FDA/EMA APIs are not called.

FluoxetineApprovedFDA/EMA
MDD, OCD, bulimia, panic
자살 사고 (항우울제 class)
ClinicalTrials.gov
EscitalopramApprovedFDA/EMA
MDD, GAD
자살 사고 (항우울제 class)
ClinicalTrials.gov

Program and pipeline notes live on BioMoa · cns · StructureMoa ↔ BioMoa bridge