ADHD stimulant / non-stimulant series

ADHDNot analyzed

Phenethylamine and piperidine pharmacophores — methylphenidate, amphetamine and atomoxetine.

Mechanism · ADHD BioMoa · ADHD / CNS BioMoa bridge · shared ID

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Data sources: Catalog seed
Last updated: Not recorded
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 6
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

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Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Phenethylamine pharmacophoreAbstract pharmacophoreadhd-phenethylamine-corePage	Scaffold	`NCCC1=CC=CC=C1`	—	—	ADHD · core · monoamine · Shared pharmacophore / core scaffold. Anchor for the ADHD stimulant / non-stimulant series…
Amphetamine (Adderall component)Verified drugamphetaminePage	Drug	`CC(CC1=CC=CC=C1)N`	Phenethylamine pharmacophore	—	ADHD · FDA · approved · DAT/NET release · Approved therapeutic. Amphetamine (Adderall component) in this family map.
Atomoxetine (Strattera)Verified drugatomoxetinePage	Drug	`CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2`	Phenethylamine pharmacophore	—	ADHD · FDA · approved · NET inhibitor · Approved therapeutic. Atomoxetine (Strattera) in this family map.
Guanfacine (Intuniv)Verified drugguanfacinePage	Drug	`NC(=N)NC1=CC=CC(Cl)=C1Cl`	Phenethylamine pharmacophore	—	ADHD · FDA · approved · α2A agonist · non-stimulant · Approved therapeutic. Guanfacine (Intuniv) in this family map.
Lisdexamfetamine (Vyvanse)Verified druglisdexamfetaminePage	Drug	`CC(CC1=CC=CC=C1)NC(=O)[C@@H](N)CCCCN`	Phenethylamine pharmacophore	—	ADHD · FDA · approved · prodrug · amphetamine · Approved therapeutic. Lisdexamfetamine (Vyvanse) in this family map.
Methylphenidate (Ritalin)Verified drugmethylphenidatePage	Drug	`COC(=O)C(C1CCCCN1)C2=CC=CC=C2`	Phenethylamine pharmacophore	—	ADHD · FDA · approved · DAT inhibitor · Approved therapeutic. Methylphenidate (Ritalin) in this family map.
Viloxazine (Qelbree)Verified drugviloxazinePage	Drug	`CCOC1=CC=CC=C1OC(C)CN`	Phenethylamine pharmacophore	—	ADHD · FDA · approved · NET inhibitor · non-stimulant · Approved therapeutic. Viloxazine (Qelbree) in this family map.
Fluoro-phenethylamine analogExploratory analog (rule-generated)adhd-fluoro-phenethylaminePage	Derivative	`CC(CC1=CC=C(C=C1)F)N`	Phenethylamine pharmacophore	—	SAR · F-scan · SAR exploration node. Derived analog of parent node in ADHD stimulant / non-stimulant seri…

Name	Role	Derived from	Sim. to core	Relations	Tags
Amphetamine (Adderall component)Verified drug	Drug	Phenethylamine pharmacophore	—	derived_from: Phenethylamine pharmacophore · similar_to: Methylphenidate (Ritalin) · similar_to: Lisdexamfetamine (Vyvanse)	ADHD, FDA, approved, DAT/NET release
Atomoxetine (Strattera)Verified drug	Drug	Phenethylamine pharmacophore	—	derived_from: Phenethylamine pharmacophore · related_drug: Methylphenidate (Ritalin) · similar_to: Viloxazine (Qelbree)	ADHD, FDA, approved, NET inhibitor
Fluoro-phenethylamine analogExploratory analog (rule-generated)	Derivative	Phenethylamine pharmacophore	—	derived_from: Phenethylamine pharmacophore	SAR, F-scan
Guanfacine (Intuniv)Verified drug	Drug	Phenethylamine pharmacophore	—	derived_from: Phenethylamine pharmacophore · related_drug: Lisdexamfetamine (Vyvanse)	ADHD, FDA, approved, α2A agonist, non-stimulant
Lisdexamfetamine (Vyvanse)Verified drug	Drug	Phenethylamine pharmacophore	—	derived_from: Phenethylamine pharmacophore · similar_to: Amphetamine (Adderall component) · related_drug: Guanfacine (Intuniv)	ADHD, FDA, approved, prodrug, amphetamine
Methylphenidate (Ritalin)Verified drug	Drug	Phenethylamine pharmacophore	—	derived_from: Phenethylamine pharmacophore · similar_to: Amphetamine (Adderall component) · related_drug: Atomoxetine (Strattera)	ADHD, FDA, approved, DAT inhibitor
Phenethylamine pharmacophoreAbstract pharmacophore	Scaffold	—	—	derived_from: Methylphenidate (Ritalin) · derived_from: Atomoxetine (Strattera) · derived_from: Amphetamine (Adderall component) · derived_from: Lisdexamfetamine (Vyvanse) · derived_from: Guanfacine (Intuniv) · derived_from: Viloxazine (Qelbree) · derived_from: Fluoro-phenethylamine analog	ADHD, core, monoamine
Viloxazine (Qelbree)Verified drug	Drug	Phenethylamine pharmacophore	—	derived_from: Phenethylamine pharmacophore · similar_to: Atomoxetine (Strattera)	ADHD, FDA, approved, NET inhibitor, non-stimulant

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