| Pyrrolidinone carboxamide coreAbstract pharmacophoreaed-carboxamide-corePage | Scaffold | CC(=O)NC1CC1 | — | — | AED · core · Shared pharmacophore / core scaffold. Anchor for the Antiepileptic drug chemical series li… |
| Carbamazepine (Tegretol)Known compoundcarbamazepinePage | Drug | NC(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 | Pyrrolidinone carboxamide core | 8%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | AED · dibenzazepine · Clinical or approved drug node — Carbamazepine (Tegretol). · CHEMBL108 · CID 2554 |
| Lamotrigine (Lamictal)Known compoundlamotriginePage | Drug | NC1=NC(N)=C(N=N1)C2=C(Cl)C=CC=C2Cl | Pyrrolidinone carboxamide core | 0%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | AED · triazine · Clinical or approved drug node — Lamotrigine (Lamictal). · CHEMBL696 · CID 3878 |
| Levetiracetam (Keppra)Exploratory analoglevetiracetamPage | Drug | CC[C@H](C)C(=O)N | Pyrrolidinone carboxamide core | 14%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | AED · SV2A · Clinical or approved drug node — Levetiracetam (Keppra). |
| Topiramate (Topamax)Verified drugtopiramatePage | Drug | CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N… | Pyrrolidinone carboxamide core | — | AED · FDA · approved · sulfamate · Approved therapeutic. Topiramate (Topamax) in this family map. |
| Valproic acid (Depakote)Verified drugvalproic-acidPage | Drug | CCCC(CCC)C(=O)O | Pyrrolidinone carboxamide core | — | AED · FDA · approved · mood stabilizer · Approved therapeutic. Valproic acid (Depakote) in this family map. |
| Ethyl homolog analogExploratory analog (rule-generated)levetiracetam-ethyl-homologPage | Derivative | CCC(=O)N | Pyrrolidinone carboxamide core | 17%iStructural similarity calculated using Morgan fingerprint (RDKit circular fingerprint, radius 2, 2048 bits) with Tanimoto similarity. Structural similarity does not predict biological equivalence, potency, safety, or clinical efficacy. | SAR · SAR exploration node. Derived analog of parent node in Antiepileptic drug chemical series. |