Antiepileptic drug chemical series

Antiepileptic · AEDRefresh recommended

Carboxamide and tricyclic pharmacophores — levetiracetam, carbamazepine, lamotrigine.

Mechanism · Antiepileptic · AED BioMoa · GABAergic / CNS BioMoa bridge · shared ID

Last analysis: 7/20/2026, 2:06:22 AM · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed · PubChem · ChEMBL
Last updated: 7/20/2026, 2:06:22 AM
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 4
Exploratory nodes: 2
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Pyrrolidinone carboxamide coreAbstract pharmacophoreaed-carboxamide-corePage	Scaffold	`CC(=O)NC1CC1`	—	—	AED · core · Shared pharmacophore / core scaffold. Anchor for the Antiepileptic drug chemical series li…
Carbamazepine (Tegretol)Known compoundcarbamazepinePage	Drug	`NC(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31`	Pyrrolidinone carboxamide core	8%i	AED · dibenzazepine · Clinical or approved drug node — Carbamazepine (Tegretol). · CHEMBL108 · CID 2554
Lamotrigine (Lamictal)Known compoundlamotriginePage	Drug	`NC1=NC(N)=C(N=N1)C2=C(Cl)C=CC=C2Cl`	Pyrrolidinone carboxamide core	0%i	AED · triazine · Clinical or approved drug node — Lamotrigine (Lamictal). · CHEMBL696 · CID 3878
Levetiracetam (Keppra)Exploratory analoglevetiracetamPage	Drug	`CC[C@H](C)C(=O)N`	Pyrrolidinone carboxamide core	14%i	AED · SV2A · Clinical or approved drug node — Levetiracetam (Keppra).
Topiramate (Topamax)Verified drugtopiramatePage	Drug	`CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N…`	Pyrrolidinone carboxamide core	—	AED · FDA · approved · sulfamate · Approved therapeutic. Topiramate (Topamax) in this family map.
Valproic acid (Depakote)Verified drugvalproic-acidPage	Drug	`CCCC(CCC)C(=O)O`	Pyrrolidinone carboxamide core	—	AED · FDA · approved · mood stabilizer · Approved therapeutic. Valproic acid (Depakote) in this family map.
Ethyl homolog analogExploratory analog (rule-generated)levetiracetam-ethyl-homologPage	Derivative	`CCC(=O)N`	Pyrrolidinone carboxamide core	17%i	SAR · SAR exploration node. Derived analog of parent node in Antiepileptic drug chemical series.

Name	Role	Derived from	Sim. to core	Relations	Tags
Carbamazepine (Tegretol)Known compound	Drug	Pyrrolidinone carboxamide core	8%i	similar_to: Lamotrigine (Lamictal) · related_drug: Levetiracetam (Keppra) · similar_to: Pyrrolidinone carboxamide core · derived_from: Pyrrolidinone carboxamide core	AED, dibenzazepine
Ethyl homolog analogExploratory analog (rule-generated)	Derivative	Pyrrolidinone carboxamide core	17%i	derived_from: Pyrrolidinone carboxamide core · similar_to: Pyrrolidinone carboxamide core	SAR
Lamotrigine (Lamictal)Known compound	Drug	Pyrrolidinone carboxamide core	0%i	similar_to: Carbamazepine (Tegretol) · similar_to: Pyrrolidinone carboxamide core · derived_from: Pyrrolidinone carboxamide core	AED, triazine
Levetiracetam (Keppra)Exploratory analog	Drug	Pyrrolidinone carboxamide core	14%i	derived_from: Pyrrolidinone carboxamide core · related_drug: Carbamazepine (Tegretol) · similar_to: Pyrrolidinone carboxamide core	AED, SV2A
Pyrrolidinone carboxamide coreAbstract pharmacophore	Scaffold	—	—	derived_from: Levetiracetam (Keppra) · derived_from: Ethyl homolog analog · similar_to: Levetiracetam (Keppra) · similar_to: Carbamazepine (Tegretol) · similar_to: Lamotrigine (Lamictal) · similar_to: Ethyl homolog analog · derived_from: Topiramate (Topamax) · derived_from: Valproic acid (Depakote) · derived_from: Carbamazepine (Tegretol) · derived_from: Lamotrigine (Lamictal)	AED, core
Topiramate (Topamax)Verified drug	Drug	Pyrrolidinone carboxamide core	—	derived_from: Pyrrolidinone carboxamide core · related_drug: Valproic acid (Depakote)	AED, FDA, approved, sulfamate
Valproic acid (Depakote)Verified drug	Drug	Pyrrolidinone carboxamide core	—	derived_from: Pyrrolidinone carboxamide core · related_drug: Topiramate (Topamax)	AED, FDA, approved, mood stabilizer

Loading map…