Atypical antipsychotic series

AntipsychoticNot analyzed

Piperazine and benzisoxazole pharmacophores — aripiprazole, risperidone, olanzapine and quetiapine.

Mechanism · Antipsychotic BioMoa · Antipsychotic / CNS BioMoa bridge · shared ID

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Data sources: Catalog seed · ClinicalTrials.gov · FDA/EMA
Last updated: Not recorded
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 4
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

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Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Piperazine aryl pharmacophoreAbstract pharmacophoreantipsychotic-piperazine-corePage	Scaffold	`C1CN(CCN1)CC2=CC=CC=C2`	—	—	antipsychotic · core · D2 · Shared pharmacophore / core scaffold. Anchor for the Atypical antipsychotic series lineage…
Aripiprazole (Abilify)Verified drugaripiprazolePage	Drug	`C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C…`	Piperazine aryl pharmacophore	—	antipsychotic · FDA · approved · D2 partial agonist · Approved therapeutic. Aripiprazole (Abilify) in this family map.
Olanzapine (Zyprexa)Verified drugolanzapinePage	Drug	`CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C`	Piperazine aryl pharmacophore	—	antipsychotic · FDA · approved · thienobenzodiazepine · Approved therapeutic. Olanzapine (Zyprexa) in this family map.
Quetiapine (Seroquel)Verified drugquetiapinePage	Drug	`C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C…`	Piperazine aryl pharmacophore	—	antipsychotic · FDA · approved · dibenzothiazepine · Approved therapeutic. Quetiapine (Seroquel) in this family map.
Risperidone (Risperdal)Verified drugrisperidonePage	Drug	`CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5…`	Piperazine aryl pharmacophore	—	antipsychotic · FDA · approved · D2 antagonist · Approved therapeutic. Risperidone (Risperdal) in this family map.
Fluoro-piperazine analogExploratory analog (rule-generated)antipsychotic-fluoro-piperazinePage	Derivative	`C1CN(CCN1CC2=CC=CC=C2)CC3=CC=C(C=C3)F`	Piperazine aryl pharmacophore	—	SAR · F-scan · SAR exploration node. Derived analog of parent node in Atypical antipsychotic series.

Name	Role	Derived from	Sim. to core	Relations	Tags
Aripiprazole (Abilify)Verified drug	Drug	Piperazine aryl pharmacophore	—	derived_from: Piperazine aryl pharmacophore · related_drug: Risperidone (Risperdal)	antipsychotic, FDA, approved, D2 partial agonist
Fluoro-piperazine analogExploratory analog (rule-generated)	Derivative	Piperazine aryl pharmacophore	—	derived_from: Piperazine aryl pharmacophore	SAR, F-scan
Olanzapine (Zyprexa)Verified drug	Drug	Piperazine aryl pharmacophore	—	derived_from: Piperazine aryl pharmacophore	antipsychotic, FDA, approved, thienobenzodiazepine
Piperazine aryl pharmacophoreAbstract pharmacophore	Scaffold	—	—	derived_from: Aripiprazole (Abilify) · derived_from: Risperidone (Risperdal) · derived_from: Olanzapine (Zyprexa) · derived_from: Quetiapine (Seroquel) · derived_from: Fluoro-piperazine analog	antipsychotic, core, D2
Quetiapine (Seroquel)Verified drug	Drug	Piperazine aryl pharmacophore	—	derived_from: Piperazine aryl pharmacophore · similar_to: Risperidone (Risperdal)	antipsychotic, FDA, approved, dibenzothiazepine
Risperidone (Risperdal)Verified drug	Drug	Piperazine aryl pharmacophore	—	derived_from: Piperazine aryl pharmacophore · similar_to: Quetiapine (Seroquel) · related_drug: Aripiprazole (Abilify)	antipsychotic, FDA, approved, D2 antagonist

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Clinical · regulatory context

비정형 항정신병

D2/5-HT2A 계열. 대사·QT·사망률(노인 치매) 경고가 공통입니다.

Approved/clinical labels here come from the catalog clinical overlay. Agency names are shown when curated; live FDA/EMA APIs are not called.

AripiprazoleApprovedFDA/EMA
Schizophrenia, bipolar, adjunct MDD
노인 치매 관련 정신병 — 사망 위험 증가
ClinicalTrials.gov
OlanzapineApprovedFDA/EMA
Schizophrenia, bipolar
노인 치매 관련 정신병 — 사망 위험 증가
ClinicalTrials.gov

Program and pipeline notes live on BioMoa · cns · StructureMoa ↔ BioMoa bridge