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StructureMoaOncology · CNS · cardio-metabolic · ADC catalog

Derivative · BCL-2 inhibitor · BCL-2 inhibitor · Exploratory analog (rule-generated)

BCL-2 SAR sulfonamide analog structure · mechanism

2D chemical structure

BCL-2 SAR sulfonamide analog 2D structure

Role
Derivative
Mechanism class
BCL-2 inhibitor
Parent scaffold
Venetoclax (Venclexta)
Structure source
StructureMoa-defined exploratory analog

How similarity is calculated

SMILES

CC1(CCC(=C(C1)c2ccc(Cl)cc2)CN3CCN(CC3)c4ccc(C(=O)NS(=O)(=O)c5ccccc5)c(OC)c4)C

Tags

SAR

Related compounds

External IDs · BioMoa

PubChem 검색ChEMBL 검색PubChem (SMILES)BioMoa · BioMoa에서 검색BioMoa · BCL-2 inhibitorBioMoa bridgeOpen on the family mapFlowStructure tableMechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

BCL-2 SAR sulfonamide analog structure · BCL-2 inhibitor | StructureMoa