BCL-2 BH3-mimetic inhibitor series

BCL-2 inhibitorRefresh recommended

BH3-mimetic scaffold to venetoclax, navitoclax, sonrotoclax and SAR analogs.

Mechanism · BCL-2 inhibitor BioMoa · BCL-2 inhibitor BioMoa bridge · shared ID

Last analysis: 7/20/2026, 2:06:28 AM · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed
Last updated: 7/20/2026, 2:06:28 AM
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 4
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
BH3-mimetic scaffoldAbstract pharmacophorebh3-mimetic-corePage	Scaffold	`c1ccc(cc1)S(=O)(=O)Nc2ccccc2`	—	—	BCL-2 · core · Shared pharmacophore / core scaffold. Anchor for the BCL-2 BH3-mimetic inhibitor series li…
Lisaftoclax (APG-2575)Known compoundlisaftoclaxPage	Drug	`CC1(CCC(=C(C1)c2ccc(Cl)cc2)CN3CCN(CC3)c4cc…`	BH3-mimetic scaffold	12%i	clinical · BCL-2 · Clinical-stage candidate. Lisaftoclax (APG-2575) in this family map.
Navitoclax (ABT-263)Known compoundnavitoclaxPage	Drug	`CC1(CCC(=C(C1)c2ccc(Cl)cc2)CN3CCN(CC3)c4cc…`	BH3-mimetic scaffold	14%i	clinical · BCL-2/xL · Clinical-stage candidate. Navitoclax (ABT-263) in this family map.
Sonrotoclax (BGB-11417)Known compoundsonrotoclaxPage	Drug	`CC1(CCC(=C(C1)c2ccc(F)cc2)CN3CCN(CC3)c4ccc…`	BH3-mimetic scaffold	12%i	clinical · BCL-2 · Clinical-stage candidate. Sonrotoclax (BGB-11417) in this family map.
Venetoclax (Venclexta)Verified drugvenetoclaxPage	Drug	`CC1=CC(=CC(=C1)C2=CC(=CC=C2)C3=CC(=CC=C3)C…`	BH3-mimetic scaffold	12%i	approved · BCL-2 · Approved therapeutic. Venetoclax (Venclexta) in this family map.
BCL-2 SAR sulfonamide analogExploratory analog (rule-generated)bcl2-sar-sulfonamidePage	Derivative	`CC1(CCC(=C(C1)c2ccc(Cl)cc2)CN3CCN(CC3)c4cc…`	Venetoclax (Venclexta)	18%i	SAR · SAR exploration node. Derived analog of parent node in BCL-2 BH3-mimetic inhibitor series.

From the core chemical, derivatives, drugs, and payloads fan out. Dashed orange chords are drug–drug links (spider web).

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