Dabrafenib (Tafinlar) structure · BRAF / MEK

Dabrafenib (Tafinlar) 2D structure

Role: Drug
Family: BRAF / MEK inhibitor chemical series
Mechanism class: BRAF / MEK
Parent scaffold: BRAF hinge-binding aryl core

Structure source: Catalog seed (external identifier on file)
PubChem CID: 44462760
ChEMBL ID: CHEMBL2028663

How similarity is calculated

Hand-written analysis

Mechanism

다브라페닙도 BRAF V600 type I 저해제입니다. 베무라페닙과 적응은 겹치고, 열·발진 프로파일은 약마다 다릅니다. 단독보다 MEK 병용이 내성·피부 독성을 줄입니다.

Medicinal chemistry

티아졸 카르복사마이드 코어입니다. 트라메티닙과 고정 병용 데이터가 두껍습니다.

Indication · context

흑색종·NSCLC 등 V600 종양에 쓰입니다. BRAF/MEK 허브의 한 축입니다.

SMILES

CC(C)(C)C1=NC(=C(S1)C2=NC3=CC=CC=C3N2C)C4=C(C(=CC=C4)NS(=O)(=O)C)F

Related compounds

External IDs · BioMoa

PubChem CID 44462760 CHEMBL2028663 BioMoa · BRAF / Tafinlar BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

Dabrafenib (Tafinlar) structure · mechanism