BioJungboMoaKRMediMoa
StructureMoaOncology · CNS · cardio-metabolic · ADC catalog

Derivative · BRAF / MEK · BRAF / MEK · Exploratory analog

Dabrafenib + trametinib (combo) structure · mechanism

2D chemical structure

Dabrafenib + trametinib (combo) 2D structure

Role
Derivative
Mechanism class
BRAF / MEK
Parent scaffold
Dabrafenib (Tafinlar)
Structure source
StructureMoa-defined exploratory node

How similarity is calculated

SMILES

CC(C)(C)C1=NC(=C(S1)C2=NC3=CC=CC=C3N2C)C4=C(C(=CC=C4)NS(=O)(=O)C)F.CN1C(=O)C2=C(N=C(N=C2N)N3CCN(CC3)C(=O)C=C)N(C1=O)C4=CC(=C(C=C4)I)F

Tags

combinationclinical

Related compounds

External IDs · BioMoa

PubChem 검색ChEMBL 검색PubChem (SMILES)BioMoa · BioMoa에서 검색BioMoa · BRAF inhibitorBioMoa bridgeOpen on the family mapFlowStructure tableMechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology