Cognitive modulator series

Cognition · dementiaRefresh recommended

Cholinesterase and NMDA pharmacophores — donepezil, rivastigmine, memantine.

Mechanism · Cognition · dementia BioMoa · GABAergic / CNS BioMoa bridge · shared ID

Last analysis: 7/20/2026, 2:07:02 AM · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed · PubChem · ChEMBL · ClinicalTrials.gov · FDA/EMA
Last updated: 7/20/2026, 2:07:02 AM
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 3
Exploratory nodes: 2
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
N-benzylpiperidine pharmacophoreAbstract pharmacophorecog-piperidine-pharmacophorePage	Scaffold	`C1CCN(CC1)CC2=CC=CC=C2`	—	—	AChE · core · Shared pharmacophore / core scaffold. Anchor for the Cognitive modulator series lineage.
Donepezil (Aricept)Verified drugdonepezilPage	Drug	`COC1=CC2=C(C=C1OC)C(=O)C(CC3CCN(CC3)CC4=CC…`	N-benzylpiperidine pharmacophore	33%i	AChEi · Alzheimer · Clinical or approved drug node — Donepezil (Aricept). · CHEMBL502 · CID 3152
Galantamine (Razadyne)Verified druggalantaminePage	Drug	`CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O`	N-benzylpiperidine pharmacophore	—	AChEi · FDA · approved · Alzheimer · Approved therapeutic. Galantamine (Razadyne) in this family map.
Memantine (Namenda)Verified drugmemantinePage	Drug	`CC12CC3CC(C)(C1)CC(N)(C3)C2`	N-benzylpiperidine pharmacophore	3%i	NMDA · adamantane · Clinical or approved drug node — Memantine (Namenda). · CHEMBL558 · CID 4054
Rivastigmine (Exelon)Exploratory analogrivastigminePage	Drug	`CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C`	N-benzylpiperidine pharmacophore	10%i	AChEi · carbamate · Clinical or approved drug node — Rivastigmine (Exelon).
Demethoxy donepezil analogExploratory analog (rule-generated)donepezil-demethoxy-analogPage	Derivative	`OC1=CC2=C(C=C1)C(=O)C(CC3CCN(CC3)CC4=CC=CC…`	N-benzylpiperidine pharmacophore	35%i	SAR · SAR exploration node. Derived analog of parent node in Cognitive modulator series.

From the core chemical, derivatives, drugs, and payloads fan out. Dashed orange chords are drug–drug links (spider web).

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Clinical · regulatory context

치매 — AChE / NMDA

Donepezil·galantamine·rivastigmine(AChEi)과 memantine(NMDA) 병용 맥락이 일반적입니다.

Approved/clinical labels here come from the catalog clinical overlay. Agency names are shown when curated; live FDA/EMA APIs are not called.

DonepezilApprovedFDA/EMA
Alzheimer dementia (mild–severe)
ClinicalTrials.gov
MemantineApprovedFDA/EMA
Moderate–severe Alzheimer
ClinicalTrials.gov

Program and pipeline notes live on BioMoa · cns · StructureMoa ↔ BioMoa bridge