CGRP gepant migraine series

Migraine · CGRP gepantNot analyzed

Urea / amide CGRP receptor antagonists — ubrogepant, rimegepant and atogepant for acute and preventive migraine.

Mechanism · Migraine · CGRP gepant BioMoa · Migraine / CNS BioMoa bridge · shared ID

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Data sources: Catalog seed · ClinicalTrials.gov · FDA
Last updated: Not recorded
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 3
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
CGRP urea / amide pharmacophoreAbstract pharmacophorecgrp-urea-corePage	Scaffold	`CC(C)(C)NC(=O)N1CCNCC1`	—	—	CGRP · core · gepant · urea · Shared pharmacophore / core scaffold. Anchor for the CGRP gepant migraine series lineage.
Atogepant (Qulipta)Verified drugatogepantPage	Drug	`CC(C)(C)NC(=O)N1CCN(CC1)C2=NC3=C(C=CC(=C3)…`	CGRP urea / amide pharmacophore	—	CGRP · FDA · approved · gepant · preventive · Approved therapeutic. Atogepant (Qulipta) in this family map.
Rimegepant (Nurtec ODT)Verified drugrimegepantPage	Drug	`CC(C)(C)NC(=O)N1CCN(CC1)C2=NC3=C(C=CC(=C3)…`	CGRP urea / amide pharmacophore	—	CGRP · FDA · approved · gepant · acute · Approved therapeutic. Rimegepant (Nurtec ODT) in this family map.
Ubrogepant (Ubrelvy)Verified drugubrogepantPage	Drug	`CC(C)(C)NC(=O)N1CCN(CC1)C2=NC3=CC=CC=C3N2C…`	CGRP urea / amide pharmacophore	—	CGRP · FDA · approved · gepant · acute · Approved therapeutic. Ubrogepant (Ubrelvy) in this family map.
Fluoro-benzimidazole gepant analogExploratory analog (rule-generated)cgrp-fluoro-benzimidazolePage	Derivative	`CC(C)(C)NC(=O)N1CCN(CC1)C2=NC3=C(C=CC(=C3)…`	CGRP urea / amide pharmacophore	—	SAR · F-scan · SAR exploration node. Derived analog of parent node in CGRP gepant migraine series.

From the core chemical, derivatives, drugs, and payloads fan out. Dashed orange chords are drug–drug links (spider web).

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Clinical · regulatory context

편두통 — CGRP gepant

Triptan과 다른 케모타입. 심혈관 금기가 상대적으로 적고 예방·급성 용도가 나뉩니다.

Approved/clinical labels here come from the catalog clinical overlay. Agency names are shown when curated; live FDA/EMA APIs are not called.

UbrogepantApprovedFDA
Acute migraine
ClinicalTrials.gov
RimegepantApprovedFDA
Acute + preventive migraine
ClinicalTrials.gov

Program and pipeline notes live on BioMoa · cns · StructureMoa ↔ BioMoa bridge