CGRP gepant migraine series

Migraine · CGRP gepantNot analyzed

Urea / amide CGRP receptor antagonists — ubrogepant, rimegepant and atogepant for acute and preventive migraine.

Mechanism · Migraine · CGRP gepant BioMoa · Migraine / CNS BioMoa bridge · shared ID

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Data sources: Catalog seed · ClinicalTrials.gov · FDA
Last updated: Not recorded
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 3
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
CGRP urea / amide pharmacophoreAbstract pharmacophorecgrp-urea-corePage	Scaffold	`CC(C)(C)NC(=O)N1CCNCC1`	—	—	CGRP · core · gepant · urea · Shared pharmacophore / core scaffold. Anchor for the CGRP gepant migraine series lineage.
Atogepant (Qulipta)Verified drugatogepantPage	Drug	`CC(C)(C)NC(=O)N1CCN(CC1)C2=NC3=C(C=CC(=C3)…`	CGRP urea / amide pharmacophore	—	CGRP · FDA · approved · gepant · preventive · Approved therapeutic. Atogepant (Qulipta) in this family map.
Rimegepant (Nurtec ODT)Verified drugrimegepantPage	Drug	`CC(C)(C)NC(=O)N1CCN(CC1)C2=NC3=C(C=CC(=C3)…`	CGRP urea / amide pharmacophore	—	CGRP · FDA · approved · gepant · acute · Approved therapeutic. Rimegepant (Nurtec ODT) in this family map.
Ubrogepant (Ubrelvy)Verified drugubrogepantPage	Drug	`CC(C)(C)NC(=O)N1CCN(CC1)C2=NC3=CC=CC=C3N2C…`	CGRP urea / amide pharmacophore	—	CGRP · FDA · approved · gepant · acute · Approved therapeutic. Ubrogepant (Ubrelvy) in this family map.
Fluoro-benzimidazole gepant analogExploratory analog (rule-generated)cgrp-fluoro-benzimidazolePage	Derivative	`CC(C)(C)NC(=O)N1CCN(CC1)C2=NC3=C(C=CC(=C3)…`	CGRP urea / amide pharmacophore	—	SAR · F-scan · SAR exploration node. Derived analog of parent node in CGRP gepant migraine series.

Name	Role	Derived from	Sim. to core	Relations	Tags
Atogepant (Qulipta)Verified drug	Drug	CGRP urea / amide pharmacophore	—	derived_from: CGRP urea / amide pharmacophore · similar_to: Rimegepant (Nurtec ODT) · related_drug: Rimegepant (Nurtec ODT)	CGRP, FDA, approved, gepant, preventive
CGRP urea / amide pharmacophoreAbstract pharmacophore	Scaffold	—	—	derived_from: Ubrogepant (Ubrelvy) · derived_from: Rimegepant (Nurtec ODT) · derived_from: Atogepant (Qulipta) · derived_from: Fluoro-benzimidazole gepant analog	CGRP, core, gepant, urea
Fluoro-benzimidazole gepant analogExploratory analog (rule-generated)	Derivative	CGRP urea / amide pharmacophore	—	derived_from: CGRP urea / amide pharmacophore	SAR, F-scan
Rimegepant (Nurtec ODT)Verified drug	Drug	CGRP urea / amide pharmacophore	—	derived_from: CGRP urea / amide pharmacophore · similar_to: Ubrogepant (Ubrelvy) · similar_to: Atogepant (Qulipta) · related_drug: Ubrogepant (Ubrelvy) · related_drug: Atogepant (Qulipta)	CGRP, FDA, approved, gepant, acute, preventive
Ubrogepant (Ubrelvy)Verified drug	Drug	CGRP urea / amide pharmacophore	—	derived_from: CGRP urea / amide pharmacophore · similar_to: Rimegepant (Nurtec ODT) · related_drug: Rimegepant (Nurtec ODT)	CGRP, FDA, approved, gepant, acute

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Clinical · regulatory context

편두통 — CGRP gepant

Triptan과 다른 케모타입. 심혈관 금기가 상대적으로 적고 예방·급성 용도가 나뉩니다.

Approved/clinical labels here come from the catalog clinical overlay. Agency names are shown when curated; live FDA/EMA APIs are not called.

UbrogepantApprovedFDA
Acute migraine
ClinicalTrials.gov
RimegepantApprovedFDA
Acute + preventive migraine
ClinicalTrials.gov

Program and pipeline notes live on BioMoa · cns · StructureMoa ↔ BioMoa bridge