Migraine triptan series

Migraine · triptanNot analyzed

Indole / tryptamine 5-HT1B/1D agonists — sumatriptan, rizatriptan, zolmitriptan, naratriptan and eletriptan.

Mechanism · Migraine · triptan BioMoa · Migraine / CNS BioMoa bridge · shared ID

No analysis recorded yet · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed · ClinicalTrials.gov · FDA/EMA
Last updated: Not recorded
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 5
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Indole tryptamine pharmacophoreAbstract pharmacophoretriptan-indole-corePage	Scaffold	`C1=CC=C2C(=C1)C=CN2CCN`	—	—	triptan · core · 5-HT1B/1D · Shared pharmacophore / core scaffold. Anchor for the Migraine triptan series lineage.
Eletriptan (Relpax)Verified drugeletriptanPage	Drug	`CN1CCCC1CC2=CNC3=C2C=C(C=C3)CCS(=O)(=O)C4=…`	Indole tryptamine pharmacophore	—	triptan · FDA · approved · Approved therapeutic. Eletriptan (Relpax) in this family map.
Naratriptan (Amerge)Verified drugnaratriptanPage	Drug	`CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C`	Indole tryptamine pharmacophore	—	triptan · FDA · approved · 5-HT1B/1D · Approved therapeutic. Naratriptan (Amerge) in this family map.
Rizatriptan (Maxalt)Verified drugrizatriptanPage	Drug	`CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3`	Indole tryptamine pharmacophore	—	triptan · FDA · approved · Approved therapeutic. Rizatriptan (Maxalt) in this family map.
Sumatriptan (Imitrex)Verified drugsumatriptanPage	Drug	`CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C`	Indole tryptamine pharmacophore	—	triptan · FDA · approved · 5-HT1B/1D · Approved therapeutic. Sumatriptan (Imitrex) in this family map.
Zolmitriptan (Zomig)Verified drugzolmitriptanPage	Drug	`CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3`	Indole tryptamine pharmacophore	—	triptan · FDA · approved · 5-HT1B/1D · Approved therapeutic. Zolmitriptan (Zomig) in this family map.
Methyl-indole triptan analogExploratory analog (rule-generated)triptan-methyl-indolePage	Derivative	`CNCC1=CNC2=CC=CC=C21`	Indole tryptamine pharmacophore	—	SAR · SAR exploration node. Derived analog of parent node in Migraine triptan series.

Name	Role	Derived from	Sim. to core	Relations	Tags
Eletriptan (Relpax)Verified drug	Drug	Indole tryptamine pharmacophore	—	derived_from: Indole tryptamine pharmacophore · related_drug: Sumatriptan (Imitrex)	triptan, FDA, approved
Indole tryptamine pharmacophoreAbstract pharmacophore	Scaffold	—	—	derived_from: Sumatriptan (Imitrex) · derived_from: Rizatriptan (Maxalt) · derived_from: Eletriptan (Relpax) · derived_from: Zolmitriptan (Zomig) · derived_from: Naratriptan (Amerge) · derived_from: Methyl-indole triptan analog	triptan, core, 5-HT1B/1D
Methyl-indole triptan analogExploratory analog (rule-generated)	Derivative	Indole tryptamine pharmacophore	—	derived_from: Indole tryptamine pharmacophore	SAR
Naratriptan (Amerge)Verified drug	Drug	Indole tryptamine pharmacophore	—	derived_from: Indole tryptamine pharmacophore · similar_to: Zolmitriptan (Zomig) · related_drug: Zolmitriptan (Zomig)	triptan, FDA, approved, 5-HT1B/1D
Rizatriptan (Maxalt)Verified drug	Drug	Indole tryptamine pharmacophore	—	derived_from: Indole tryptamine pharmacophore · similar_to: Sumatriptan (Imitrex)	triptan, FDA, approved
Sumatriptan (Imitrex)Verified drug	Drug	Indole tryptamine pharmacophore	—	derived_from: Indole tryptamine pharmacophore · similar_to: Rizatriptan (Maxalt) · related_drug: Eletriptan (Relpax)	triptan, FDA, approved, 5-HT1B/1D
Zolmitriptan (Zomig)Verified drug	Drug	Indole tryptamine pharmacophore	—	derived_from: Indole tryptamine pharmacophore · similar_to: Naratriptan (Amerge) · related_drug: Naratriptan (Amerge)	triptan, FDA, approved, 5-HT1B/1D

Loading map…

Clinical · regulatory context

편두통 — 5-HT1B/1D triptan

Sumatriptan 계열. 심혈관 금기가 class 이슈입니다. gepant(CGRP)는 별도 계열.

Approved/clinical labels here come from the catalog clinical overlay. Agency names are shown when curated; live FDA/EMA APIs are not called.

SumatriptanApprovedFDA/EMA
Acute migraine
ClinicalTrials.gov

Program and pipeline notes live on BioMoa · cns · StructureMoa ↔ BioMoa bridge