Drug · Neuropathic · gabapentinoid · Neuropathic · gabapentinoid · Verified drug
Duloxetine (Cymbalta) structure · mechanism
Duloxetine (Cymbalta) 2D structure
- Role
- Drug
- Mechanism class
- Neuropathic · gabapentinoid
- Parent scaffold
- Gabapentinoid amino-acid core
- Indication
- DPN, chronic MSK pain, depression · FDA/EMA
- Structure source
- Catalog seed (external identifier on file)
- PubChem CID
- 60835
- ChEMBL ID
- CHEMBL1175
- FDA / EMA
- FDA/EMA
- ClinicalTrials.gov
- duloxetine diabetic neuropathy
- Regulatory status
- Approved · FDA/EMA · ClinicalTrials.gov · ClinicalTrials.gov
Hand-written analysis
Mechanism
둘록세틴은 SERT와 NET를 비교적 균형 있게 막는 SNRI입니다. 당뇨신경병증·섬유근육통 등 통증 적응이 있습니다. 간독성·혈압을 모니터링합니다.
Medicinal chemistry
나프탈렌 티오펜 프로판아민입니다. CYP1A2·2D6 대사입니다.
Indication · context
우울과 신경병증 통증을 한 분자로 잇는 약입니다. 가바펜티노이드와 기전 층이 다릅니다.
SMILES
CNCC[C@@H](Oc1cccc2ccccc12)c1cccs1Tags
Related compounds
Comparisons · briefs
External IDs · BioMoa
StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.