Drug · Neuropathic · gabapentinoid · Neuropathic · gabapentinoid · Verified drug
Gabapentin (Neurontin) structure · mechanism
Gabapentin (Neurontin) 2D structure
- Role
- Drug
- Mechanism class
- Neuropathic · gabapentinoid
- Parent scaffold
- Gabapentinoid amino-acid core
- Structure source
- Catalog seed
Hand-written analysis
Mechanism
가바펜틴은 α2δ에 결합해 칼슘채널 트래피킹을 줄입니다. GABA 작용제가 아닙니다. 흡수 포화가 있어 PK가 비선형입니다.
Medicinal chemistry
GABA 유사 아미노산이지만 GABA-A에 붙지 않습니다. 프레가발린보다 생체이용이 들쭉날쭉합니다.
Indication · context
신경병증 통증·일부 간질. SNRI 통증 약과 층을 섞지 마십시오.
SMILES
NCC1(CCCCC1)CC(=O)OTags
Related compounds
External IDs · BioMoa
StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.