Sleep / hypnotic series

Sleep · hypnoticNot analyzed

Imidazopyridine Z-drugs, dual orexin receptor antagonists (DORAs) — zolpidem, zaleplon, eszopiclone, suvorexant, lemborexant and daridorexant.

Mechanism · Sleep · hypnotic BioMoa · Sleep / CNS BioMoa bridge · shared ID

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Data sources: Catalog seed · ClinicalTrials.gov · FDA/EMA · FDA
Last updated: Not recorded
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 6
Exploratory nodes: 1
Abstract scaffolds: 1
Relationship types: Derived (curated) · Drug-class link · Fingerprint similarity

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Imidazopyridine pharmacophoreAbstract pharmacophoresleep-imidazopyridine-corePage	Scaffold	`CC1=NC=C2C(=N1)C=CC=C2`	—	—	hypnotic · core · GABA-A · Shared pharmacophore / core scaffold. Anchor for the Sleep / hypnotic series lineage.
Daridorexant (Quviviq)Verified drugdaridorexantPage	Drug	`CC1=NC(=C(N1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)N…`	Imidazopyridine pharmacophore	—	hypnotic · FDA · approved · DORA · Approved therapeutic. Daridorexant (Quviviq) in this family map.
Eszopiclone (Lunesta)Verified drugeszopiclonePage	Drug	`CN(C(=O)C1=NC(=CN1C)C2=CC=CC=C2S(=O)(=O)C)…`	Imidazopyridine pharmacophore	—	hypnotic · FDA · approved · Z-drug · GABA-A · Approved therapeutic. Eszopiclone (Lunesta) in this family map.
Lemborexant (Dayvigo)Verified druglemborexantPage	Drug	`CC1=CC=C(C=C1)C(=O)N2CCC(CC2)N3CCN(CC3)C4=…`	Imidazopyridine pharmacophore	—	hypnotic · FDA · approved · DORA · Approved therapeutic. Lemborexant (Dayvigo) in this family map.
Suvorexant (Belsomra)Verified drugsuvorexantPage	Drug	`CC1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)…`	Imidazopyridine pharmacophore	—	hypnotic · FDA · approved · DORA · Approved therapeutic. Suvorexant (Belsomra) in this family map.
Zaleplon (Sonata)Verified drugzaleplonPage	Drug	`CN1C(=O)C(C2=CC=CC=C2)=C(C3=CC=CC=N3)N1CC`	Imidazopyridine pharmacophore	—	hypnotic · FDA · approved · Z-drug · GABA-A · Approved therapeutic. Zaleplon (Sonata) in this family map.
Zolpidem (Ambien)Verified drugzolpidemPage	Drug	`CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)…`	Imidazopyridine pharmacophore	—	hypnotic · FDA · approved · GABA-A · Approved therapeutic. Zolpidem (Ambien) in this family map.
Des-methyl zolpidem analogExploratory analog (rule-generated)zolpidem-des-methyl-analogPage	Derivative	`CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)…`	Imidazopyridine pharmacophore	—	SAR · SAR exploration node. Derived analog of parent node in Sleep / hypnotic series.

Name	Role	Derived from	Sim. to core	Relations	Tags
Daridorexant (Quviviq)Verified drug	Drug	Imidazopyridine pharmacophore	—	derived_from: Imidazopyridine pharmacophore · similar_to: Lemborexant (Dayvigo) · related_drug: Lemborexant (Dayvigo)	hypnotic, FDA, approved, DORA
Des-methyl zolpidem analogExploratory analog (rule-generated)	Derivative	Imidazopyridine pharmacophore	—	derived_from: Imidazopyridine pharmacophore	SAR
Eszopiclone (Lunesta)Verified drug	Drug	Imidazopyridine pharmacophore	—	derived_from: Imidazopyridine pharmacophore · similar_to: Zolpidem (Ambien)	hypnotic, FDA, approved, Z-drug, GABA-A
Imidazopyridine pharmacophoreAbstract pharmacophore	Scaffold	—	—	derived_from: Zolpidem (Ambien) · derived_from: Suvorexant (Belsomra) · derived_from: Zaleplon (Sonata) · derived_from: Eszopiclone (Lunesta) · derived_from: Lemborexant (Dayvigo) · derived_from: Daridorexant (Quviviq) · derived_from: Des-methyl zolpidem analog	hypnotic, core, GABA-A
Lemborexant (Dayvigo)Verified drug	Drug	Imidazopyridine pharmacophore	—	derived_from: Imidazopyridine pharmacophore · similar_to: Suvorexant (Belsomra) · similar_to: Daridorexant (Quviviq) · related_drug: Daridorexant (Quviviq)	hypnotic, FDA, approved, DORA
Suvorexant (Belsomra)Verified drug	Drug	Imidazopyridine pharmacophore	—	derived_from: Imidazopyridine pharmacophore · related_drug: Zolpidem (Ambien) · similar_to: Lemborexant (Dayvigo)	hypnotic, FDA, approved, DORA
Zaleplon (Sonata)Verified drug	Drug	Imidazopyridine pharmacophore	—	derived_from: Imidazopyridine pharmacophore · similar_to: Zolpidem (Ambien)	hypnotic, FDA, approved, Z-drug, GABA-A
Zolpidem (Ambien)Verified drug	Drug	Imidazopyridine pharmacophore	—	derived_from: Imidazopyridine pharmacophore · related_drug: Suvorexant (Belsomra) · similar_to: Zaleplon (Sonata) · similar_to: Eszopiclone (Lunesta)	hypnotic, FDA, approved, GABA-A

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Clinical · regulatory context

수면 — Z-drug / DORA

Zolpidem class와 orexin 길항제(DORA)는 작용기전이 다릅니다. 낙상·의존 경고 주의.

Approved/clinical labels here come from the catalog clinical overlay. Agency names are shown when curated; live FDA/EMA APIs are not called.

ZolpidemApprovedFDA/EMA
Insomnia (short-term)
ClinicalTrials.gov
LemborexantApprovedFDA
Insomnia (DORA)
ClinicalTrials.gov

Program and pipeline notes live on BioMoa · cns · StructureMoa ↔ BioMoa bridge