Drug · Statin / HMG-CoA · Statin / HMG-CoA · Verified drug
Atorvastatin (Lipitor) structure · mechanism
Atorvastatin (Lipitor) 2D structure
- Role
- Drug
- Mechanism class
- Statin / HMG-CoA
- Parent scaffold
- Dihydroxyheptanoate pharmacophore
- Indication
- Hyperlipidemia / ASCVD prevention · FDA/EMA
- Structure source
- Catalog seed (external identifier on file)
- PubChem CID
- 60823
- ChEMBL ID
- CHEMBL1487
- FDA / EMA
- FDA/EMA
- ClinicalTrials.gov
- atorvastatin cardiovascular
- Regulatory status
- Approved · FDA/EMA · ClinicalTrials.gov · ClinicalTrials.gov
Hand-written analysis
Mechanism
아토르바스타틴은 HMG-CoA 환원효소를 저해해 간 콜레스테롤 합성을 막고 LDL 수용체를 올립니다. 고강도 스타틴입니다. CYP3A 상호작용·근육 증상이 고전적입니다.
Medicinal chemistry
피롤 코어에 헵탄산 모사 측쇄가 있습니다. 친유성 스타틴으로 분류됩니다.
Indication · context
죽상경화 예방·LDL-C 강하의 1차 경구제입니다. 로수바스타틴과 강도·친수성을 비교합니다.
SMILES
CC(C)C1=C(C(=C(N1CC[C@@H](C[C@@H](C[C@@H](C(=O)O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4Tags
Related compounds
External IDs · BioMoa
StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.