Rosuvastatin (Crestor) structure · Statin / HMG-CoA

Rosuvastatin (Crestor) 2D structure

Role: Drug
Family: Statin HMG-CoA reductase inhibitor series
Mechanism class: Statin / HMG-CoA
Parent scaffold: Dihydroxyheptanoate pharmacophore
Indication: Hyperlipidemia / high-intensity statin · FDA/EMA

Structure source: Catalog seed (external identifier on file)
PubChem CID: 446157
FDA / EMA: FDA/EMA
ClinicalTrials.gov: rosuvastatin LDL
Regulatory status: Approved · FDA/EMA · ClinicalTrials.gov · ClinicalTrials.gov

How similarity is calculated

Hand-written analysis

Mechanism

로수바스타틴도 HMG-CoA 환원효소 저해로 LDL-C를 내립니다. 고강도이며 친수성 쪽으로 분류됩니다. OATP1B1 변이가 노출에 영향을 줍니다.

Medicinal chemistry

피리미딘 설폰아마이드 코어입니다. 아토르바스타틴의 피롤과 케모타입이 다릅니다.

Indication · context

고강도 스타틴 선택지입니다. PCSK9 제제와는 표적 층이 다릅니다.

SMILES

CC(C)C1=NC(=NC(=C1C2=CC=C(C=C2)F)C(=O)N[C@@H](CC3=CC=C(C=C3)S(=O)(=O)N)C(=O)O)C(C)(C)O

Related compounds

External IDs · BioMoa

PubChem CID 446157 ChEMBL 검색 BioMoa · Statin / Crestor BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

Rosuvastatin (Crestor) structure · mechanism