Mini Map

임상 · 규제 맥락

Statin — HMG-CoA 환원효소

LDL-C 1차 요법. 고효능(atorva/rosuva) vs 수용성(prava) 케모타입 구분.

Atorvastatin승인FDA/EMA
Hyperlipidemia / ASCVD prevention
ClinicalTrials.gov
Rosuvastatin승인FDA/EMA
Hyperlipidemia / high-intensity statin
ClinicalTrials.gov

약물명 · 2D 구조식 · SMILES · 역할 · 파생 출처 · core 유사도 · 특성(태그·노트)을 맵 위에 텍스트로 요약합니다. 행을 클릭하면 상세가 열립니다.

약물 / 화합물	역할	구조식 (SMILES)	파생 출처	Core 유사	특성
Dihydroxyheptanoate pharmacophorestatin-hmg-core	Scaffold	`CC(C)(C)C(O)CC(O)CC(=O)O`	—	—	statin · core · HMG-CoA · Shared pharmacophore / core scaffold. Anchor for the Statin HMG-CoA reductase inhibitor se…
Atorvastatin (Lipitor)atorvastatin	Drug	`CC(C)C1=C(C(=C(N1CC[C@@H](C[C@@H](C[C@@H](…`	Dihydroxyheptanoate pharmacophore	—	statin · FDA · approved · LDL-C · Approved therapeutic. Atorvastatin (Lipitor) in this family map.
Pravastatin (Pravachol)pravastatin	Drug	`CC(C)C[C@H](C(=O)O)[C@@H]1CC[C@@H]2[C@H]1[…`	Dihydroxyheptanoate pharmacophore	—	statin · FDA · approved · LDL-C · hydrophilic · Approved therapeutic. Pravastatin (Pravachol) in this family map.
Rosuvastatin (Crestor)rosuvastatin	Drug	`CC(C)C1=NC(=NC(=C1C2=CC=C(C=C2)F)C(=O)N[C@…`	Dihydroxyheptanoate pharmacophore	—	statin · FDA · approved · LDL-C · potent · Approved therapeutic. Rosuvastatin (Crestor) in this family map.
Simvastatin (Zocor)simvastatin	Drug	`CCC(C)(C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@…`	Dihydroxyheptanoate pharmacophore	—	statin · FDA · approved · LDL-C · lactone prodrug · Approved therapeutic. Simvastatin (Zocor) in this family map.
Fluoro-phenyl statin analogstatin-fluoro-phenyl-analog	Derivative	`CC(C)(C)C(O)CC(O)CC(=O)OC1=CC=C(C=C1)F`	Dihydroxyheptanoate pharmacophore	—	SAR · F-scan · SAR exploration node. Derived analog of parent node in Statin HMG-CoA reductase inhibitor …

중심 core chemical에서 바깥 링으로 파생·drug·payload가 퍼지고, 점선·주황 chord는 drug 간 연결(spider web)입니다.

파생Core → analog → drug/payload 합성·SAR 경로

유사성구조 유사도 (FP)

Drug 연결동일 계열·경쟁·플랫폼 drug 간 spider 링크

접합Payload–linker–ADC 조립

노드를 드래그해 배치를 조정하고, 클릭하면 2D 구조식이 표시됩니다.

맵 로딩 중…