DM4 (soravtansine) structure · Maytansinoid

DM4 (soravtansine) 2D structure

Role: Payload
Family: DM1 / maytansinoid payload family
Mechanism class: Maytansinoid
Parent scaffold: Maytansine core

Structure source: Catalog seed

How similarity is calculated

Hand-written analysis

Mechanism

DM4(라브탄신)는 메이탄시노이드 미세소관 저해제입니다. DM1보다 소수성·막투과가 커서 절단 링커와 짝을 이루면 bystander가 열립니다.

Medicinal chemistry

메이탄신 C3에 메틸디티올 핸들입니다. SMCC-DM1(비절단)과 링커 화학이 다릅니다.

Indication · context

ravtansine ADC의 payload입니다. DM1·MMAE·DXd와 전달 층을 나눕니다.

SMILES

CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C(C)C2OC1CC1C(C)(C)c3cc4cc(OC)c(OC)c4cc3C21CNC

Related compounds

External IDs · BioMoa

PubChem 검색 ChEMBL 검색 PubChem (SMILES)BioMoa · BioMoa에서 검색 BioMoa · Maytansinoid ADC BioMoa · Taxane / microtubule BioMoa bridge Open on the family map Flow Structure table Mechanism class

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Methodology

DM4 (soravtansine) structure · mechanism