DM1 / maytansinoid payload family

MaytansinoidRefresh recommended

Maytansine-derived microtubule inhibitors — DM1 and DM4 used in Kadcyla and related ADCs.

Mechanism · Maytansinoid BioMoa · Maytansinoid ADC BioMoa · Taxane / microtubule BioMoa bridge · shared ID

Last analysis: 7/20/2026, 2:07:04 AM · 2 weeks cadence · refresh on /analyze · refresh recommended

Data sources: Catalog seed · PubChem · ChEMBL
Last updated: 7/20/2026, 2:07:04 AM
Similarity method: Morgan fingerprint, radius 2, 2048 bits, Tanimoto
Verified / known compounds: 1
Exploratory nodes: 7
Abstract scaffolds: 1
Relationship types: Derived (curated) · Fingerprint similarity · Conjugate · Drug-class link

StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.

Spider Web · Flow · Structure table · Compare · SMILES map

Name, 2D structure, SMILES, role, parent, core similarity, and traits. Click a row for details.

Compound	Role	SMILES	Parent	Core sim.	Traits
Maytansine coreAbstract pharmacophoremaytansine-corePage	Scaffold	`CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C…`	—	—	maytansinoid · microtubule · core · Shared pharmacophore / core scaffold. Anchor for the DM1 / maytansinoid payload family lin…
DM1 N-de methyl analogExploratory analog (rule-generated)dm-sar-1Page	Derivative	`CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C…`	DM1 (mertansine)	—	SAR · SAR exploration node. Derived analog of parent node in DM1 / maytansinoid payload family.
DM1 (mertansine)Payloaddm1Page	Payload	`CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C…`	Maytansine core	—	ADC · payload · Kadcyla · Maytansinoid microtubule inhibitor payload (Kadcyla). · CHEMBL2103840 · CID 11343137
DM4 (soravtansine)Payloaddm4Page	Payload	`CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C…`	Maytansine core	—	ADC · payload · Dimethyl analog — increased potency vs DM1.
SN-38 payload (cross-family)Payloadsn38-payload-nodePage	Payload	`CCC1=C2[C@@H](C[C@@H](O2)N(C1=O)[C@@H]3C[C…`	Maytansine core	—	payload · TOP1 · Illustrative TOP1 payload node in maytansinoid map.
SMCC-DM1 (linker-payload)Linkersmcc-dm1-linkerPage	Linker	`O=C(C=C)NCCCC[C@@H]1NC(=O)CNC1.CN1C(=O)C2O…`	DM1 (mertansine)	—	linker · non-cleavable · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines …
Ado-trastuzumab emtansine (Kadcyla)ADCado-trastuzumab-emtansinePage	ADC	`CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C…`	DM1 (mertansine)	—	ADC · approved · HER2 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Ado-trastuz…
Bivatuzumab mertansineADCbivatuzumab-mertansinePage	ADC	`CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C…`	DM4 (soravtansine)	—	ADC · CD44 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Bivatuzumab…
Sacituzumab govitecan (Trodelvy)ADCsacituzumab-govitecanPage	ADC	`CCC1=C2[C@@H](C[C@@H](O2)N(C1=O)[C@@H]3C[C…`	SN-38 payload (cross-family)	—	ADC · approved · TOP1 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Sacituzumab…

Core → SAR → final drug/ADC development path.

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