| Maytansine coreAbstract pharmacophoremaytansine-corePage | Scaffold | CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C… | — | — | maytansinoid · microtubule · core · Shared pharmacophore / core scaffold. Anchor for the DM1 / maytansinoid payload family lin… |
| DM1 N-de methyl analogExploratory analog (rule-generated)dm-sar-1Page | Derivative | CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C… | DM1 (mertansine) | — | SAR · SAR exploration node. Derived analog of parent node in DM1 / maytansinoid payload family. |
| DM1 (mertansine)Payloaddm1Page | Payload | CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C… | Maytansine core | — | ADC · payload · Kadcyla · Maytansinoid microtubule inhibitor payload (Kadcyla). · CHEMBL2103840 · CID 11343137 |
| DM4 (soravtansine)Payloaddm4Page | Payload | CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C… | Maytansine core | — | ADC · payload · Dimethyl analog — increased potency vs DM1. |
| SN-38 payload (cross-family)Payloadsn38-payload-nodePage | Payload | CCC1=C2[C@@H](C[C@@H](O2)N(C1=O)[C@@H]3C[C… | Maytansine core | — | payload · TOP1 · Illustrative TOP1 payload node in maytansinoid map. |
| SMCC-DM1 (linker-payload)Linkersmcc-dm1-linkerPage | Linker | O=C(C=C)NCCCC[C@@H]1NC(=O)CNC1.CN1C(=O)C2O… | DM1 (mertansine) | — | linker · non-cleavable · Linker for antibody conjugation. Connects antibody to payload; cleavage chemistry defines … |
| Ado-trastuzumab emtansine (Kadcyla)ADCado-trastuzumab-emtansinePage | ADC | CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C… | DM1 (mertansine) | — | ADC · approved · HER2 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Ado-trastuz… |
| Bivatuzumab mertansineADCbivatuzumab-mertansinePage | ADC | CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C… | DM4 (soravtansine) | — | ADC · CD44 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Bivatuzumab… |
| Sacituzumab govitecan (Trodelvy)ADCsacituzumab-govitecanPage | ADC | CCC1=C2[C@@H](C[C@@H](O2)N(C1=O)[C@@H]3C[C… | SN-38 payload (cross-family) | — | ADC · approved · TOP1 · Antibody-drug conjugate construct; displayed structure is the payload warhead (Sacituzumab… |