Payload · Maytansinoid · Maytansinoid · Payload
DM1 (mertansine) structure · mechanism
Maytansinoid microtubule inhibitor payload (Kadcyla).
DM1 (mertansine) 2D structure
- Role
- Payload
- Mechanism class
- Maytansinoid
- Aliases
- mertansine, emtansine
- Parent scaffold
- Maytansine core
- Structure source
- Catalog seed (external identifier on file)
- PubChem CID
- 11343137
- ChEMBL ID
- CHEMBL2103840
Hand-written analysis
Mechanism
DM1(메르탄신)은 메이탄시노이드 미세소관 저해제입니다. T-DM1에서는 비절단 SMCC 링커로 항체 분해 후 라이신-MCC-DM1이 남습니다. bystander가 MMAE·DXd보다 제한적인 편입니다.
Medicinal chemistry
메이탄신 C3 에스테르에 티올 핸들(DM1)이 있습니다. DM4는 디메틸과 다른 링커 화학입니다.
Indication · context
ado-trastuzumab emtansine의 payload입니다. HER2 ADC에서 DXd(엔허투)와 전달·bystander를 비교하는 것이 핵심입니다.
SMILES
CN1C(=O)C2OCC(=O)C(C)(OC(=O)C)C2(OC(=O)C)C(C)C2OC1CC1C(C)(C)c3cc4cc(OC)c(OC)c4cc3C21CTags
Related compounds
Comparisons · briefs
External IDs · BioMoa
StructureMoa is a chemical-structure exploration tool. Structural similarity, clustering, and SAR relationships are intended for research exploration and do not establish shared potency, selectivity, safety, efficacy, or clinical performance.